MQO1_STAEQ
ID MQO1_STAEQ Reviewed; 492 AA.
AC Q5HLN0;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Probable malate:quinone oxidoreductase 1 {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO 1 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] 1 {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo1 {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=SERP1955;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; CP000029; AAW52837.1; -; Genomic_DNA.
DR RefSeq; WP_001831551.1; NC_002976.3.
DR AlphaFoldDB; Q5HLN0; -.
DR STRING; 176279.SERP1955; -.
DR EnsemblBacteria; AAW52837; AAW52837; SERP1955.
DR GeneID; 50017961; -.
DR KEGG; ser:SERP1955; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_9; -.
DR OMA; PHLDTRW; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; -; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1..492
FT /note="Probable malate:quinone oxidoreductase 1"
FT /id="PRO_0000128753"
SQ SEQUENCE 492 AA; 55032 MW; A0791686F3969AD3 CRC64;
MNTQHSKTDV ILIGGGIMSA TLGTLLKELT PEKDIQLFER LSQPGEESSN VWNNAGTGHS
ALCELNYTKE GKDGSVDITK AIHINEQFQI SKQFWAYLIR EGHIESPDKF IQSVPHMSFV
KGEENVKFLK SRVASLQKNV LFEKMKISQD PEKINSWVPL MMEGRQSDEA IAITYDETGT
DVNFGALTKK LIANLQQKNV GINYKHEVLD IKKLNNGNWQ VVVKDLNTSN VMNYESKFVF
IGAGGASLPL LQKTKIKESK HIGGFPVSGL FLRCKNPDVI HRHHAKVYGK AEVGAPPMSV
PHLDTRFVNG EKSLLFGPFA GFSPKFLKNG SYLDLVKSVK PNNMITMLSA GVKEFNLTKY
LVSQLMLSNE ERINDLRVFL PEAKDEDWEV ITAGQRVQVI KDTDKSKGQL QFGTEVITSE
DGSLAALLGA SPGASTAVDI MFDVLQRCYK SEFKSWEPKI KEMVPSFGLK LSEHEDMYHS
INEEVKKYLN VK
