MQO1_STAES
ID MQO1_STAES Reviewed; 492 AA.
AC Q8CN91;
DT 15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Probable malate:quinone oxidoreductase 1 {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO 1 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] 1 {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo1 {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=SE_1943;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO05584.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE015929; AAO05584.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_765498.1; NC_004461.1.
DR RefSeq; WP_002485540.1; NC_004461.1.
DR AlphaFoldDB; Q8CN91; -.
DR STRING; 176280.SE_1943; -.
DR EnsemblBacteria; AAO05584; AAO05584; SE_1943.
DR KEGG; sep:SE_1943; -.
DR PATRIC; fig|176280.10.peg.1896; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_9; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; -; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT CHAIN 1..492
FT /note="Probable malate:quinone oxidoreductase 1"
FT /id="PRO_0000128749"
SQ SEQUENCE 492 AA; 55032 MW; 172B374234417E62 CRC64;
MNTQHSKTDV ILIGGGIMSA TLGTLLKELT PEKDIQLFER LSQPGEESSN VWNNAGTGHS
ALCELNYTKE GKDGSVDITK AIHINEQFQL SKQFWAYLIR EGHIESPDKF IQSVPHMSFV
KGEENVKFLK SRVASLQKNV LFEKMKISQD PEKINSWVPL MMEGRQSDEA IAITYDETGT
DVNFGALTKK LIANLQQKNV GINYKHEVLD IKKLNNGNWQ VVVKDLNTSN VMNYESKFVF
IGAGGASLPL LQKTKIKESK HIGGFPVSGL FLRCKNPDVI HRHHAKVYGK AEVGAPPMSV
PHLDTRFVNG EKSLLFGPFA GFSPKFLKNG SYLDLVKSVK PNNMITMLSA GVKEFNLTKY
LVSQLMLSNE ERINDLRVFL PEAKDEDWEV ITAGQRVQVI KDTDKSKGQL QFGTEVITSE
DGSLAALLGA SPGASTAVDI MFDVLQRCYK SEFKSWEPKI KEMVPSFGLK LSEHEDMYHS
INEEVKKYLN VK
