MQO2_PSEAE
ID MQO2_PSEAE Reviewed; 507 AA.
AC Q9HVF1;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Probable malate:quinone oxidoreductase 2 {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO 2 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] 2 {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo2 {ECO:0000255|HAMAP-Rule:MF_00212}; Synonyms=mqoB;
GN OrderedLocusNames=PA4640;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 17933;
RA Kretzschmar U., Goerisch H.;
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY129296; AAN01356.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG08028.1; -; Genomic_DNA.
DR PIR; G83065; G83065.
DR RefSeq; NP_253330.1; NC_002516.2.
DR RefSeq; WP_003099345.1; NZ_QZGE01000029.1.
DR AlphaFoldDB; Q9HVF1; -.
DR STRING; 287.DR97_1949; -.
DR PaxDb; Q9HVF1; -.
DR PRIDE; Q9HVF1; -.
DR DNASU; 881249; -.
DR EnsemblBacteria; AAG08028; AAG08028; PA4640.
DR GeneID; 881249; -.
DR KEGG; pae:PA4640; -.
DR PATRIC; fig|208964.12.peg.4861; -.
DR PseudoCAP; PA4640; -.
DR HOGENOM; CLU_028151_0_0_6; -.
DR InParanoid; Q9HVF1; -.
DR OMA; RCDNPEV; -.
DR PhylomeDB; Q9HVF1; -.
DR BioCyc; PAER208964:G1FZ6-4736-MON; -.
DR BRENDA; 1.1.5.4; 5087.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IDA:PseudoCAP.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0006069; P:ethanol oxidation; IDA:PseudoCAP.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; -; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1..507
FT /note="Probable malate:quinone oxidoreductase 2"
FT /id="PRO_0000128730"
SQ SEQUENCE 507 AA; 55498 MW; 0A7F91E4172CAA8D CRC64;
MAQNDHETVD MLLVGAGIMS ATLAVLLKEL DPNLKMEVVE LQESGAIESS NPWNNAGTGH
AGLCELNYTP QSADGSIDIK KAVGINTMFE VSKQFWSHLV AKGTFGSPKT FINPVPHLSF
VRGSEGIAYL KKRFESLTKH HAFETMVYSE DKATLAEWMP LMMPGRPADE AIAATRVEGG
TDVNFGALTN QLLQHLAQQP GAQIRYNQKV THLRRADNGW RVTVKDTRNG GDREIQARFV
FLGAGGGALP LLQLSGIPEG KGFGGFPVSG QWLRCDNPEI VKQHQAKVYS QAEVGSPPMS
VPHLDTRVVD GKKSLLFGPY AGFSTKFLRH GSFLDLPLSV RPGNILPMLS VARDNMDLTR
YLIGQVMQSP EQRLEALRKF YPEARAEDWR LEVAGQRVQI IKKDPKKGGI LQFGTELVAA
HDGSIAALLG ASPGASVTVS IMLGLIERCF PEQARSPEWS AKLKEIFPAR EKELESDAEL
YRSVSSRCSE VLELTAKNDV QAPVNAE
