ID   MQO2_PSEPK              Reviewed;         527 AA.
AC   Q88NF9;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Probable malate:quinone oxidoreductase 2 {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO 2 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] 2 {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo2 {ECO:0000255|HAMAP-Rule:MF_00212}; Synonyms=mqo-2;
GN   OrderedLocusNames=PP_1251;
OS   Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950
OS   / KT2440).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=160488;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440;
RX   PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA   Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA   Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA   Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F.,
RA   Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M., Hance I.,
RA   Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A.,
RA   Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H.,
RA   Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C.,
RA   Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M.;
RT   "Complete genome sequence and comparative analysis of the metabolically
RT   versatile Pseudomonas putida KT2440.";
RL   Environ. Microbiol. 4:799-808(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; AE015451; AAN66875.1; -; Genomic_DNA.
DR   RefSeq; NP_743411.3; NC_002947.4.
DR   AlphaFoldDB; Q88NF9; -.
DR   STRING; 160488.PP_1251; -.
DR   PRIDE; Q88NF9; -.
DR   EnsemblBacteria; AAN66875; AAN66875; PP_1251.
DR   KEGG; ppu:PP_1251; -.
DR   PATRIC; fig|160488.4.peg.1327; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_6; -.
DR   OMA; PHLDTRW; -.
DR   PhylomeDB; Q88NF9; -.
DR   BioCyc; PPUT160488:G1G01-1338-MON; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000000556; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..527
FT                   /note="Probable malate:quinone oxidoreductase 2"
FT                   /id="PRO_0000128733"
SQ   SEQUENCE   527 AA;  58117 MW;  F7E5B8231255BF0C CRC64;
     MQAHAAETKK VDVLLVGGGI MSSTLAVWLH ELEPSWSMEM VERLDGVAEE SSNGWNNAGT
     GHSALAELNY TPEDKDGNVN ISKAIEINEA FQISRQFWSW QVRQGVLKNP HSFINTTPHM
     SFVWGDDNIK FLKKRYDALQ ASPLFRPMQY SEDHAQIAKW VPLMMEGRDP NQKLAVTWTP
     IGTDVNFGEI TRQFVGHLQT QKGFELKLSS EVQDITRNKD GSWHVEYKNL KDGTESATDA
     KFLFIGAGGG ALKLLQKSGI PEAKEYAGFP VGGSFLVTEN PTVAMQHMAK AYGIASTGAP
     PMSVPHLDTR VLDGKRVILF GPFATFSTKF LKNGSYLDLL SSTTTHNVWP MTKVGIDQYP
     LVEYLAGQLM LSDDDRFEAL RTYFPNAKKE EWRLWQAGQR VQIIKRDAEK GGVLKLGTEV
     VASEDRTIAG LLGASPGAST AAPIMLHVLE TVFKEKVATP EWQAKIKEIV PSYGTKLNDS
     AAATQKEWNY TAEVLQLGKP PVIDASVEFG GAASKPVESK PENDMAL