ID   MQO2_STAAR              Reviewed;         498 AA.
AC   Q6GDJ6;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Probable malate:quinone oxidoreductase 2 {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO 2 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] 2 {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo2 {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=SAR2685;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX571856; CAG41662.1; -; Genomic_DNA.
DR   RefSeq; WP_001130051.1; NC_002952.2.
DR   AlphaFoldDB; Q6GDJ6; -.
DR   KEGG; sar:SAR2685; -.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   OMA; RCDNPEV; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..498
FT                   /note="Probable malate:quinone oxidoreductase 2"
FT                   /id="PRO_0000128744"
SQ   SEQUENCE   498 AA;  55999 MW;  7D8D5ED706A4D183 CRC64;
     MAKSNSKDIV LIGAGVLSTT FGSMLKEIEP DWNIHVYERL DRPAIESSNE RNNAGTGHAA
     LCELNYTVLQ PDGSIDIEKA KVINEEFEIS KQFWGHLVKS GSIENPREFI NPLPHISYVR
     GKNNVKFLKD RYEAMKAFPM FDNIEYTEDI EVMKKWIPLM MKGREDNPGI MAASKIDEGT
     DVNFGELTRK MAKSIEAHPN ATVQFNHEVV DFEQLSNGQW EVTVKNRLTG EKFKQVTDYV
     FIGAGGGAIP LLQKTGIPES KHLGGFPISG QFLACTNPQV IEQHDAKVYG KEPPGTPPMT
     VPHLDTRYID GQRTLLFGPF ANVGPKFLKN GSNLDLFKSV KTYNITTLLA AAVKNLPLIK
     YSFDQVIMTK EGCMNHLRTF YPEARNEDWQ LYTAGKRVQV IKDTPEHGKG FIQFGTEVVN
     SQDHTVIALL GESPGASTSV SVALEVLERN FPEYKTEWAP KIKKMIPSYG ESLIEDEKLM
     RKIRKQTSKD LELGYYEN