ID   MQO2_STAEQ              Reviewed;         498 AA.
AC   Q5HKN2;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Probable malate:quinone oxidoreductase 2 {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO 2 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] 2 {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo2 {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=SERP2312;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000029; AAW53215.1; -; Genomic_DNA.
DR   RefSeq; WP_002470281.1; NC_002976.3.
DR   AlphaFoldDB; Q5HKN2; -.
DR   STRING; 176279.SERP2312; -.
DR   EnsemblBacteria; AAW53215; AAW53215; SERP2312.
DR   KEGG; ser:SERP2312; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   OMA; RHMAKAY; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..498
FT                   /note="Probable malate:quinone oxidoreductase 2"
FT                   /id="PRO_0000128754"
SQ   SEQUENCE   498 AA;  56220 MW;  909F6319BBA4A823 CRC64;
     MANKESKNVV IIGAGVLSTT FGSMIKELEP DWNIKLYERL DRPGIESSNE RNNAGTGHAA
     LCELNYTVQQ PDGSIDIEKA KEINEQFEIS KQFWGHLVKS GNISNPRDFI NPLPHISFVR
     GKNNVKFLKN RYEAMRNFPM FDNIEYTEDI EEMRKWMPLM MTGRTGNEIM AASKIDEGTD
     VNYGELTRKM AKSIEKHPNA DVQYNHEVIN FNRRKDGIWE VKVKNRNSGD VETVLADYVF
     IGAGGGAIPL LQKTGIPESK HLGGFPISGQ FLICTNPDVI NEHDVKVYGK EPPGTPPMTV
     PHLDTRYIDG ERTLLFGPFA NIGPKFLRNG SNLDLFKSVK PYNITTLLAS AVKNLPLIKY
     SIDQVLMTKE GCMNHLRTFY PEARDEDWQL YTAGKRVQVI KDTKEHGKGF IQFGTEVVNS
     KDHSVIALLG ESPGASTSVS VALEVLEKNF AEYEKDWTPK LQKMIPSYGK SLIDDVKLMR
     ATRKQTSKDL ELNYYESK