MQO2_STAES
ID MQO2_STAES Reviewed; 498 AA.
AC Q8CQ96;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Probable malate:quinone oxidoreductase 2 {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO 2 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] 2 {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo2 {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=SE_0266;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; AE015929; AAO03863.1; -; Genomic_DNA.
DR RefSeq; NP_763821.1; NC_004461.1.
DR RefSeq; WP_001829441.1; NZ_WBME01000037.1.
DR AlphaFoldDB; Q8CQ96; -.
DR STRING; 176280.SE_0266; -.
DR EnsemblBacteria; AAO03863; AAO03863; SE_0266.
DR GeneID; 50017659; -.
DR KEGG; sep:SE_0266; -.
DR PATRIC; fig|176280.10.peg.243; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_9; -.
DR OMA; RHMAKAY; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; -; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT CHAIN 1..498
FT /note="Probable malate:quinone oxidoreductase 2"
FT /id="PRO_0000128750"
SQ SEQUENCE 498 AA; 56222 MW; 63817210B62BDAD3 CRC64;
MANKESKNVV IIGAGVLSTT FGSMIKELEP DWNIKLYERL DRPGIESSNE RNNAGTGHAA
LCELNYTVQQ PDGSIDIEKA KEINEQFEIS KQFWGHLVKS GNISNPRDFI NPLPHISFVR
GKNNVKFLKN RYEAMRNFPM FDNIEYTEDI EEMRKWMPLM MTGRTGNEIM AASKIDEGTD
VNYGELTRKM AKSIEKHPNA DVQYNHEVIN FNRRKDGTWE VKVKNRNSGD VETVLADYVF
IGAGGGAIPL LQKTGIPESK HLGGFPISGQ FLICTNPDVI NEHDVKVYGK EPPGTPPMTV
PHLDTRYIEG ERTLLFGPFA NIGPKFLRNG SNLDLFKSVK PYNITTLLAS AVKNLPLIKY
SIDQVLMTKE GCMNHLRTFY PEARDEDWQL YTAGKRVQVI KDTKEHGKGF IQFGTEVVNS
KDHSVIALLG ESPGASTSVS VALEVLEKNF AEYEKDWTPK LQKMIPSYGK SLIDDVKLMR
ATRKQTSKDL ELNYYESK
