ID   MQO3_STAEQ              Reviewed;         494 AA.
AC   Q5HKD6;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Probable malate:quinone oxidoreductase 3 {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO 3 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] 3 {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo3 {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=SERP2412;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000029; AAW53266.1; -; Genomic_DNA.
DR   RefSeq; WP_002456786.1; NC_002976.3.
DR   AlphaFoldDB; Q5HKD6; -.
DR   STRING; 176279.SERP2412; -.
DR   EnsemblBacteria; AAW53266; AAW53266; SERP2412.
DR   KEGG; ser:SERP2412; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   OMA; EYTEDME; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 2.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..494
FT                   /note="Probable malate:quinone oxidoreductase 3"
FT                   /id="PRO_0000128755"
SQ   SEQUENCE   494 AA;  55636 MW;  F25DF5447374572D CRC64;
     MSEANHKNIV VVGAGIIGTS VATMLSKVSP NWHIDMFERL EGAGIESSNE NNNAGTGHAA
     LCELNYTVEQ DDGSIDASKA QEINEQFELS RQFWGNLVKN GDISNPEEFI QPLPHISFVM
     GPTNVNFLRK RYETLRTLPM FDTIEYTEDM ETMRKWMPLM MENREPGHQM AASKIDEGTD
     VNYGALTRKL AHYLEQKSNV SLKYNHDVVD LTQREDGKWE VVVENRETKE KVTKIADKVF
     IGAGGHSIPL LQKSGVKQRE HLGGFPISGQ FLRCTNPDII KQHAAKVYSK EPQGKPPMTV
     PHLDTRYING KQTLLFGPYA NIGPKFLKFG SNLDLFESIK PYNITTMLAS AVKNVPLIKY
     SIDQMIKTKE GCMNYLRTFI PDAKDEDWEL YTAGKRVQVI KDSEQHGKGF VVFGTEVVNS
     DDNSMIALLG ESPGASTSLS VVLEVLEKNF ADDKEAWEPV VKEMVPTYGR SLINDEKLMR
     ETRRETSKNL HLNR