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MQO3_STAES
ID   MQO3_STAES              Reviewed;         494 AA.
AC   Q8CQE8;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Probable malate:quinone oxidoreductase 3 {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO 3 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] 3 {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo3 {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=SE_0157;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO03754.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE015929; AAO03754.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_763712.1; NC_004461.1.
DR   RefSeq; WP_002455958.1; NC_004461.1.
DR   AlphaFoldDB; Q8CQE8; -.
DR   STRING; 176280.SE_0157; -.
DR   EnsemblBacteria; AAO03754; AAO03754; SE_0157.
DR   GeneID; 50017568; -.
DR   KEGG; sep:SE_0157; -.
DR   PATRIC; fig|176280.10.peg.145; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 2.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..494
FT                   /note="Probable malate:quinone oxidoreductase 3"
FT                   /id="PRO_0000128751"
SQ   SEQUENCE   494 AA;  55608 MW;  1FAA2DE8633BC1DF CRC64;
     MSEANHKNIV VVGAGIIGTS VATMLSKVSP NWHIDMFERL EGAGIESSNE NNNAGTGHAA
     LCELNYTVEQ DDGSIDASKA QEINEQFELS RQFWGNLVKN GDISNPEEFI QPLPHISFVM
     GPTNVNFLRK RYETLKTLPM FDTIEYTEDM ETMRKWMPLM MENREPGHQM AASKIDEGTD
     VNYGALTRKL AHYLEQKSNV SLKYNHDVVD LTQREDGKWE VVVENRETKE KVTKIADKVF
     IGAGGHSIPL LQKSGVKQRE HLGGFPISGQ FLRCTNPDII KQHAAKVYSK EPQGKPPMTV
     PHLDTRYING KQTLLFGPYA NIGPKFLKFG SNLDLFESIK PYNITTMLAS AVKNVPLIKY
     SIDQMIKTKE GCMNYLRTFI PDAKDEDWEL YTAGKRVQVI KDSEQHGKGF VVFGTEVVNS
     DDNSMIALLG ESPGASTSLS VVLEVLEKNF ADDKEAWEPV VKEMVPTYGR SLINDEKLMR
     ETRRETSKNL HLNR
 
 
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