ID   MQO4_STAEQ              Reviewed;         499 AA.
AC   Q5HL19;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Probable malate:quinone oxidoreductase 4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO 4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] 4 {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo4 {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=SERP2168;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000029; AAW52954.1; -; Genomic_DNA.
DR   RefSeq; WP_002477163.1; NC_002976.3.
DR   AlphaFoldDB; Q5HL19; -.
DR   STRING; 176279.SERP2168; -.
DR   EnsemblBacteria; AAW52954; AAW52954; SERP2168.
DR   KEGG; ser:SERP2168; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   OMA; KTIAPDW; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..499
FT                   /note="Probable malate:quinone oxidoreductase 4"
FT                   /id="PRO_0000128756"
SQ   SEQUENCE   499 AA;  56353 MW;  BB079D034F454DE4 CRC64;
     MAMSDKKDVV LIGAGVLSTT FGSMLKTIAP DWDIHLYERL DRPGIESSNE RNNAGTGHAA
     LCELNYTVQQ PDGSIDIEKA KEINEQFEIS KQFWGHLVKS GEIQNPKEFI NPLPHISFVR
     GKNNVKFLKD RYEAMKQFPM FDNIEYTEDI EEMRKWIPLM MKGREDKGYM AASKIDEGTD
     VNYGELTRKM AQNLKNSPNV EVQYKHEVVD FERLSNGKWS VKIKNLNNGQ VFEHQTDYVF
     IGAGGGAIPL LQKTGIPESK HLGGFPISGQ FIACTNPQVI EQHDAKVYGK EPPGTPPMTV
     PHLDTRYIDG ERTLLFGPFA NVGPKFLKHG SNLDLFKSIK PYNITTLLAS AVKNLPLIKY
     SFDQVIMTKE GCMNHLRTFY PEARDEDWQV YTAGKRVQVI KDTEENGKGF IQFGTEVVNS
     EDHSVIALLG ESPGASTSVS VALEVLEKNF PEYAKNWEPK IKKMIPSYGE SLIDDVQLMR
     KIRKQTSKDL ELGFYDKAK