MQO4_STAES
ID MQO4_STAES Reviewed; 499 AA.
AC Q8CMY4;
DT 15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Probable malate:quinone oxidoreductase 4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO 4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] 4 {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo4 {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=SE_2158;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE015929; AAO05800.1; -; Genomic_DNA.
DR RefSeq; NP_765713.1; NC_004461.1.
DR RefSeq; WP_001830651.1; NZ_WBME01000005.1.
DR AlphaFoldDB; Q8CMY4; -.
DR STRING; 176280.SE_2158; -.
DR PRIDE; Q8CMY4; -.
DR EnsemblBacteria; AAO05800; AAO05800; SE_2158.
DR GeneID; 50017766; -.
DR KEGG; sep:SE_2158; -.
DR PATRIC; fig|176280.10.peg.2108; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_9; -.
DR OMA; KTIAPDW; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; -; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT CHAIN 1..499
FT /note="Probable malate:quinone oxidoreductase 4"
FT /id="PRO_0000128752"
SQ SEQUENCE 499 AA; 56353 MW; BB079D0587E7CFE4 CRC64;
MAMSDKKDVV LIGAGVLSTT FGSMLKTIAP DWDIHLYERL DRPGIESSNE RNNAGTGHAA
LCELNYTVQQ PDGSIDIEKA KEINEQFEIS KQFWGHLVKS GEIQNPKEFI NPLPHISFVR
GKNNVKFLKD RYEAMKQFPM FDNIEYTEDI EEMRKWIPLM MKGREDKGYM AASKIDEGTD
VNYGELTRKM AQNLKNSPNV EVQYKHEVVD FERLSNGKWS VKIKNLNNGQ VFEHQTDYVF
IGAGGGAIPL LQKTGIPESK HLGGFPISGQ FIACTNPQVI EQHDAKVYGK EPPGTPPMTV
PHLDTRYIDG ERTLLFGPFA NVGPKFLKHG SNLDLFKSIK PYNITTLLAS AVKNLPLIKY
SFDQVIMTKE GCMNHLRTFY PEARDEDWQV YTAGKRVQVI KDTEENGKGF IQFGTEVVNS
EDHSVIALLG ESPGASTSVS VALEVLEKNF PEYAKDWEPK IKKMIPSYGE SLIDDVQLMR
KIRKQTSKDL ELGFYNKAK