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MQO4_STAES
ID   MQO4_STAES              Reviewed;         499 AA.
AC   Q8CMY4;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Probable malate:quinone oxidoreductase 4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO 4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] 4 {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo4 {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=SE_2158;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; AE015929; AAO05800.1; -; Genomic_DNA.
DR   RefSeq; NP_765713.1; NC_004461.1.
DR   RefSeq; WP_001830651.1; NZ_WBME01000005.1.
DR   AlphaFoldDB; Q8CMY4; -.
DR   STRING; 176280.SE_2158; -.
DR   PRIDE; Q8CMY4; -.
DR   EnsemblBacteria; AAO05800; AAO05800; SE_2158.
DR   GeneID; 50017766; -.
DR   KEGG; sep:SE_2158; -.
DR   PATRIC; fig|176280.10.peg.2108; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   OMA; KTIAPDW; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..499
FT                   /note="Probable malate:quinone oxidoreductase 4"
FT                   /id="PRO_0000128752"
SQ   SEQUENCE   499 AA;  56353 MW;  BB079D0587E7CFE4 CRC64;
     MAMSDKKDVV LIGAGVLSTT FGSMLKTIAP DWDIHLYERL DRPGIESSNE RNNAGTGHAA
     LCELNYTVQQ PDGSIDIEKA KEINEQFEIS KQFWGHLVKS GEIQNPKEFI NPLPHISFVR
     GKNNVKFLKD RYEAMKQFPM FDNIEYTEDI EEMRKWIPLM MKGREDKGYM AASKIDEGTD
     VNYGELTRKM AQNLKNSPNV EVQYKHEVVD FERLSNGKWS VKIKNLNNGQ VFEHQTDYVF
     IGAGGGAIPL LQKTGIPESK HLGGFPISGQ FIACTNPQVI EQHDAKVYGK EPPGTPPMTV
     PHLDTRYIDG ERTLLFGPFA NVGPKFLKHG SNLDLFKSIK PYNITTLLAS AVKNLPLIKY
     SFDQVIMTKE GCMNHLRTFY PEARDEDWQV YTAGKRVQVI KDTEENGKGF IQFGTEVVNS
     EDHSVIALLG ESPGASTSVS VALEVLEKNF PEYAKDWEPK IKKMIPSYGE SLIDDVQLMR
     KIRKQTSKDL ELGFYNKAK
 
 
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