MQO_BACAN
ID MQO_BACAN Reviewed; 500 AA.
AC Q81P44; Q6HXB8; Q6KRD7;
DT 15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212};
GN OrderedLocusNames=BA_2974, GBAA_2974, BAS2762;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; AE016879; AAP26794.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT32091.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT55071.1; -; Genomic_DNA.
DR RefSeq; NP_845308.1; NC_003997.3.
DR RefSeq; WP_000069158.1; NZ_WXXJ01000017.1.
DR RefSeq; YP_029020.1; NC_005945.1.
DR AlphaFoldDB; Q81P44; -.
DR STRING; 260799.BAS2762; -.
DR DNASU; 1088569; -.
DR EnsemblBacteria; AAP26794; AAP26794; BA_2974.
DR EnsemblBacteria; AAT32091; AAT32091; GBAA_2974.
DR GeneID; 45022788; -.
DR KEGG; ban:BA_2974; -.
DR KEGG; bar:GBAA_2974; -.
DR KEGG; bat:BAS2762; -.
DR PATRIC; fig|198094.11.peg.2953; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_9; -.
DR OMA; PHLDTRW; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1..500
FT /note="Probable malate:quinone oxidoreductase"
FT /id="PRO_0000128704"
SQ SEQUENCE 500 AA; 55181 MW; B1CC34883ED05EE6 CRC64;
MSNMQQKTDV ILIGAGIMSA TLGSLLKELA PEWEIKVFEK LASAGEESSN EWNNAGTGHS
ALCELNYTSE KSDGSIDISK AVKVNEQFQL SRQFWAYLVK SKLIRNPQDF IMPLPHMSLV
QGEKNVEFLK NRFEALSKNP LFQGMEFSDA PETLKKWLPL IMEGRTSNEP MAATKIDSGT
DVNFGALTRM LFDYLKTKDV ELNYKHSVEN IKRTKNGLWE VKVHDMNSGK IEHHTAKFVF
IGGGGGSLPL LQKTGIPESK HIGGFPVSGL FMVCKNQKVV EQHHAKVYGK AKVGAPPMSV
PHLDTRYIDN KKALLFGPFA GFSPKFLKTG SNLDLIGSVK PNNVLTMLAA GVKEMGLTKY
LIQQVMLSHE KRMEELREFI PNAKSEDWDI VVAGQRVQVI KDTDAGGKGT LQFGTEVVSA
ADGSIAALLG ASPGASTAVH VMLEVLEKCF PSRMVEWEGK IKEMIPSYGI SLTENPRLFQ
DLHTSTGRTL GLNEKETVHN
