ID   MQO_BACMK               Reviewed;         500 AA.
AC   A9VJG1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212};
GN   OrderedLocusNames=BcerKBAB4_2768;
OS   Bacillus mycoides (strain KBAB4) (Bacillus weihenstephanensis).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=315730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KBAB4;
RX   PubMed=17434157; DOI=10.1016/j.cbi.2007.03.003;
RA   Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C.,
RA   Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V.,
RA   Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "Extending the Bacillus cereus group genomics to putative food-borne
RT   pathogens of different toxicity.";
RL   Chem. Biol. Interact. 171:236-249(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000903; ABY43968.1; -; Genomic_DNA.
DR   RefSeq; WP_012261170.1; NC_010184.1.
DR   AlphaFoldDB; A9VJG1; -.
DR   STRING; 315730.BcerKBAB4_2768; -.
DR   EnsemblBacteria; ABY43968; ABY43968; BcerKBAB4_2768.
DR   KEGG; bwe:BcerKBAB4_2768; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   OMA; PHLDTRW; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002154; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..500
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000099868"
SQ   SEQUENCE   500 AA;  55222 MW;  C09ABBEBCA892FFE CRC64;
     MSNMQQKTDV ILIGAGIMSA TLGSLLKELA PEWEIKVFEK LANAGEESSN EWNNAGTGHS
     ALCELNYTSE KSDGSIDIGK AVKVNEQFQL SRQFWAYLVK RNLIRNPQDF IMPLPHMSLV
     QGEKNVEFLK KRFEALSKNA LFQGMEFADA PDTLKKWLPL IMEGRNSNEP MAATKIDSGT
     DVNFGALTRM LFDYLKTKNV ELNYKHSVEN IKRAKNGLWE VKVHDMNSGK IEHHTAKFVF
     IGGGGGSLPL LQKTGIPESK HIGGFPVSGL FMVCKNQKIV EQHHAKVYGK AKVGAPPMSV
     PHLDTRYIDN KKALLFGPFA GFSPKFLKTG SNLDLIGSVK PNNVLTMLAA GVKEMGLTKY
     LIQQVMLSHE KRMEELREFI PNAKSEDWDT VVAGQRVQVI KDTDAGGKGT LQFGTEVVSA
     NDGSIAALLG ASPGASTAVH VMLEVLEKCF PERILEWEPK IKEMVPSYGV SLTENPRLFQ
     ELHASTGRTL GLNEKEAVHN