MQO_BURCA
ID MQO_BURCA Reviewed; 553 AA.
AC Q1BKI8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=Bcen_4992;
OS Burkholderia cenocepacia (strain AU 1054).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=331271;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AU 1054;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K.,
RA Tiedje J.M., Richardson P.;
RT "Complete sequence of chromosome 2 of Burkholderia cenocepacia AU 1054.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; CP000379; ABF79867.1; -; Genomic_DNA.
DR AlphaFoldDB; Q1BKI8; -.
DR EnsemblBacteria; ABF79867; ABF79867; Bcen_4992.
DR KEGG; bcn:Bcen_4992; -.
DR HOGENOM; CLU_028151_0_0_4; -.
DR OMA; PHLDTRW; -.
DR UniPathway; UPA00223; UER01008.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT CHAIN 1..553
FT /note="Probable malate:quinone oxidoreductase"
FT /id="PRO_0000325489"
FT REGION 524..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 60584 MW; 113DCA21FC45E048 CRC64;
MKKGSAVIKT LRVILSALAL CVATSSAHAA DTKKVDVLLV GGGIMSSTLG VWLHELQPNW
SMTMVERLDG VALESSNGWN NAGTGHSALA ELNYTPEKAD GKVDISKAIE INESFQISRQ
FWAWQVKQGV LKNPHSFINS TPHMSFVWGD DNVRFLKKRY EALQASPLFR GMQYSEDYDQ
IKQWVPLMME GRDRNQKVAA TWTPIGTDVN FGEITRQFVG YLKTQPNFTL SLSSEVREIT
RNADGTWHVS WVKLHSDEPP QSVDAKFVFI GAGGGALHLL QASGIPEAKD YGAFPVGGSF
LVTDNPEVVK QHLAKAYGKA SVGSPPMSVP HLDTRIIDGK KIILFGPFAT FSTKFLKNGS
YFDLAKSTNL HNVAPMMRVG VDEFPLVQYL AGQLMLTDDD RFNALKEYFP NAKKEDWRLW
QAGQRVQIIK RDPVKGGVLK LGTEIVASQD GSIAGLLGAS PGASTAAPIM LNLMQKVFKD
KVATPEWQQK IRQIVPSYGT KLNDSPAKVV EEWTYTSDVL QLSPPPKIDL GAPSQATGNA
PARPAKASAD MAL
