ID   MQO_CAMJE               Reviewed;         448 AA.
AC   P56954; Q0PBB7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Probable malate:quinone oxidoreductase;
DE            EC=1.1.5.4;
DE   AltName: Full=MQO;
DE   AltName: Full=Malate dehydrogenase [quinone];
GN   Name=mqo; OrderedLocusNames=Cj0393c;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
CC   -!- FUNCTION: Catalyzes oxidation of malate to oxaloacetate in the citric
CC       acid cycle. Donates electrons to quinones of the electron transfer
CC       chain (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=The FAD is tightly bound. {ECO:0000250};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000305}.
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DR   EMBL; AL111168; CAL34543.1; -; Genomic_DNA.
DR   PIR; G81382; G81382.
DR   RefSeq; WP_002854402.1; NC_002163.1.
DR   RefSeq; YP_002343830.1; NC_002163.1.
DR   AlphaFoldDB; P56954; -.
DR   SMR; P56954; -.
DR   STRING; 192222.Cj0393c; -.
DR   PaxDb; P56954; -.
DR   PRIDE; P56954; -.
DR   DNASU; 904716; -.
DR   EnsemblBacteria; CAL34543; CAL34543; Cj0393c.
DR   GeneID; 904716; -.
DR   KEGG; cje:Cj0393c; -.
DR   PATRIC; fig|192222.6.peg.384; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_613842_0_0_7; -.
DR   OMA; DMGEAKI; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..448
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000128708"
SQ   SEQUENCE   448 AA;  50586 MW;  66D54F010F30A025 CRC64;
     MSQQEFDVLV IGAGISGAAL FYELARYTNI KNIALIEKYN TAATLNSKGT SNSQTIHCGD
     IETNYTLEKA RKVKRTADMI VKYGLMQNAQ NNFMFSHQKM ALAVGDIECD YMKKRYEEFK
     ELYPYIKFFD KAKIKQIEPK VVLGEDCNQD RPENICAMGV ESGEVFTTVD FGKMSINLIE
     QAQKQNKNTF VAFNQEIIHI EKKDDIFILK TSNHQEYHAK SVVVNAGAHS LYLAHKMNLG
     MDKSCWPVAG SFYLTKQKLL NGKVYMVQNP KLPFAALHGD PDLLADMNTR FGPTALVIPK
     LERYHGLKSV PEFFEALKLD KTVLKVTFNM FKDATIRNYI FYNYLFELPF VDKSLFVKDA
     KKIVPSLKAS DIYYAKGFGG VRPQVIDKTK GELMLGEASI TETPGIIFNM TPSPGATSCL
     GNAERDAKLV CNYLGMEFNE DKFSSELL