MQO_CORDI
ID MQO_CORDI Reviewed; 499 AA.
AC Q6NGL9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=DIP1492;
OS Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype
OS gravis).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=257309;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700971 / NCTC 13129 / Biotype gravis;
RX PubMed=14602910; DOI=10.1093/nar/gkg874;
RA Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G.,
RA Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D.,
RA De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N.,
RA Holroyd S., Jagels K., Moule S., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G.,
RA Parkhill J.;
RT "The complete genome sequence and analysis of Corynebacterium diphtheriae
RT NCTC13129.";
RL Nucleic Acids Res. 31:6516-6523(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; BX248358; CAE50019.1; -; Genomic_DNA.
DR RefSeq; WP_010935102.1; NC_002935.2.
DR AlphaFoldDB; Q6NGL9; -.
DR SMR; Q6NGL9; -.
DR STRING; 257309.DIP1492; -.
DR DNASU; 2650376; -.
DR EnsemblBacteria; CAE50019; CAE50019; DIP1492.
DR KEGG; cdi:DIP1492; -.
DR HOGENOM; CLU_028151_0_0_11; -.
DR OMA; PHLDTRW; -.
DR OrthoDB; 1371190at2; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000002198; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; -; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1..499
FT /note="Probable malate:quinone oxidoreductase"
FT /id="PRO_0000325493"
SQ SEQUENCE 499 AA; 55033 MW; A3637D30BFAC4560 CRC64;
MADSTTAQHV TDEVDVALIG AGIMSATLGA MLRTLEPGWT QVMFERLDAP AQESSSPWNN
AGTGHSALCE LNYTPEVKGR VQIDKALGVN EKFQISRQFW SYQVNEGVLP SPREWINPVP
HVSFGRGEDQ VAYLKKRYEA LAAHPLFPNM QYTDDRAKFA EMLPLMADGR SEFEKVAISW
TDAGTDINYG SQTRQFLKAA EKNGTEIRYG HEVKDIKRDG AKWRVTVKNV HTGDTQVIRA
NFVFVGAGGM ALPLLQKTGI VEIRGWGGFP VSGQWLRCTN PDIIEQHAAK VYGKASIGAP
PMSVPHLDTR VIDGEKGLLF GPYAGWTPKF LKKGSYLDLF KSIRPTNLMS YLGVGAQEFG
LTKYLITEVM KDQAARMESL REYMPNAKDE DWELVTAGQR VQAIQPVVGP RFSTLAFGTS
LINSADGSVA GILGASPGAS IAPAAMLELL ERCFGQKMVE WGPTIKDMIP SYGIRLATDQ
KLFNEIWDHT QATLQLDKK
