MQO_EXIS2
ID MQO_EXIS2 Reviewed; 497 AA.
AC B1YG64;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=Exig_3002;
OS Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 /
OS 255-15).
OC Bacteria; Firmicutes; Bacilli; Bacillales;
OC Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX NCBI_TaxID=262543;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C.,
RA Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T.,
RA Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome of Exiguobacterium sibiricum 255-15.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; CP001022; ACB62448.1; -; Genomic_DNA.
DR RefSeq; WP_012371863.1; NC_010556.1.
DR AlphaFoldDB; B1YG64; -.
DR STRING; 262543.Exig_3002; -.
DR EnsemblBacteria; ACB62448; ACB62448; Exig_3002.
DR KEGG; esi:Exig_3002; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_9; -.
DR OMA; PHLDTRW; -.
DR OrthoDB; 1371190at2; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000001681; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1..497
FT /note="Probable malate:quinone oxidoreductase"
FT /id="PRO_1000099872"
SQ SEQUENCE 497 AA; 54253 MW; F6CF3CB731DF1C72 CRC64;
MSSMPKQTDV ILIGAGVMSA TLGVLLKELA PDMKIKVFEK LASAGEESSN EWNNAGTGHA
ALCELNYTTE NADGTIDISK AVKVNEQFQL SRQFWSHLVK EQVLPNPKEF IMPIPHMSMV
EGAENVTFLK KRLEALSANP LFKGMEFSED PEQLKEWIPL IMEGRTSPEP IAATKIDSGT
DVNFGALTRI LFDHLKQLDV EINYGHGVED LKRVDGGWEI KVKNERDNRI EHHTAKFVFI
GGGGGSLPLL QKTGIPESKQ IGGFPVSGLF LVCKNPEIAE RHHAKVYGKA KVGAPPMSVP
HLDTRYIDGQ KSLLFGPFAG FSPKFLKTGS NLDLITSVKP NNVLTMLAAG AKEMGLTKYL
IEQVLLSTEQ RMNELREFIP NAKTEDWDVV VAGQRVQVIK DTPQGKGALQ FGTEVVSAAD
GSVAALLGAS PGASTAVPVM LEVLAKCFPD QLPSWEAKIK EMIPSYGTSL VANPELFDQI
HAETTKTLEL TEAQPIR