ID   MQO_GEOKA               Reviewed;         501 AA.
AC   Q5L055;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=GK1396;
OS   Geobacillus kaustophilus (strain HTA426).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=235909;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTA426;
RX   PubMed=15576355; DOI=10.1093/nar/gkh970;
RA   Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA   Matsui S., Uchiyama I.;
RT   "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT   Geobacillus kaustophilus.";
RL   Nucleic Acids Res. 32:6292-6303(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; BA000043; BAD75681.1; -; Genomic_DNA.
DR   RefSeq; WP_011230892.1; NC_006510.1.
DR   AlphaFoldDB; Q5L055; -.
DR   STRING; 235909.GK1396; -.
DR   EnsemblBacteria; BAD75681; BAD75681; GK1396.
DR   KEGG; gka:GK1396; -.
DR   PATRIC; fig|235909.7.peg.1508; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   OMA; PHLDTRW; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000001172; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..501
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000023801"
SQ   SEQUENCE   501 AA;  55200 MW;  C58460F1D2AC4831 CRC64;
     MGNKQGKMDV ILIGAGIMSA TLGTLLKELA PEWDIVVFER LEEAGAESSN EWNNAGTGHA
     ALCELNYTVE KADGSIDIGK AIKINEQFYV SLQFWAYLVN SGILRDPKDF VRPLPHMSFV
     QGEDNVAFLK KRHETMAANP LFKGMEFTDD PKKLAEWVPL MMEGRVVDEP IAATRIESGT
     DVNFGALTRQ LFEHLKRKNV EIRYRHHVED IKRTSDGLWE LKVRNLDTGT VELHAAKFVF
     IGAGGGSLHL LQKSGIPEGK GIGGFPVSGL FMVCNNPEVV EQHHAKVYGK AKVGAPPMSV
     PHLDTRFIDN QKMLLFGPFA GFSPKFLKNG SMLDLFTSIK PHNVLTILAA GVKNMSLTNY
     LIQQVLLSKE QRMQELREFV PTAKSDEWDI VVAGQRVQVI KDTESGGKGT LQFGTEVVHA
     ADGSIAALLG ASPGASTAVH VMLEVMEKCF PERMNEWRAK VKEMIPSYGE SLMKNEALLR
     QVQASTAEAL GLNGHFAMQL A