ID   MQO_GEOSW               Reviewed;         509 AA.
AC   C5DAE0;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=GWCH70_1433;
OS   Geobacillus sp. (strain WCH70).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   unclassified Geobacillus.
OX   NCBI_TaxID=471223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WCH70;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Brumm P., Mead D.A., Richardson P.;
RT   "Complete sequence of chromosome of Geopacillus sp. WCH70.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP001638; ACS24254.1; -; Genomic_DNA.
DR   AlphaFoldDB; C5DAE0; -.
DR   STRING; 471223.GWCH70_1433; -.
DR   EnsemblBacteria; ACS24254; ACS24254; GWCH70_1433.
DR   KEGG; gwc:GWCH70_1433; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   OMA; PHLDTRW; -.
DR   UniPathway; UPA00223; UER01008.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..509
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000204200"
FT   REGION          490..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  56362 MW;  53728A62FC8BF4A7 CRC64;
     MSNRQTSTDV ILIGAGIMSA TLGTLLKELA PEWEIKVFEK LGKPGEESSN EWNNAGTGHA
     ALCELNYTPE KPDGSIDISK AIRINEQFQV SKQFWAYLVK NNLLQNPQEF IRPLPHISLV
     QGENNVRFLK KRFEALSNNP LFQGMEFSDD PEKLKEWMPL IMEGRTSNEP IAATKIDSGT
     DVNFGALTRM LFDHLKRKGV EINYKHSVKD IKRTSDGLWE LKVKDLNSGS VEIHKAKFVF
     IGAGGGSLHL LQKSGIPEGK HIGGFPVSGL FMVCNNPKVV EKHHAKVYGK AKIGAPPMSV
     PHLDTRYIDN KKMLLFGPFA GFSPKFLKNG SNMDLFASVK LHNLGTLLAS AFKNFSLEKY
     LIQQLMLTKE KRMEELREFV PTAKSEDWDI VIAGQRVQII KDTEAGGKGT IQFGTEVVSA
     ADGSIAALLG ASPGASTAVH VMLEVLKKCF PQHMKEWEPK IKEMIPSYGV SLAKNPDLFQ
     KLHDSTAETL GLNEKEPVSG ASEKELVYS