ID   MQO_GEOTN               Reviewed;         501 AA.
AC   A4IMR6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=GTNG_1250;
OS   Geobacillus thermodenitrificans (strain NG80-2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=420246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NG80-2;
RX   PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA   Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA   Han W., Peng X., Liu R., Wang L.;
RT   "Genome and proteome of long-chain alkane degrading Geobacillus
RT   thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000557; ABO66620.1; -; Genomic_DNA.
DR   RefSeq; WP_011887231.1; NC_009328.1.
DR   AlphaFoldDB; A4IMR6; -.
DR   STRING; 420246.GTNG_1250; -.
DR   EnsemblBacteria; ABO66620; ABO66620; GTNG_1250.
DR   KEGG; gtn:GTNG_1250; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   OMA; PHLDTRW; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000001578; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..501
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000023802"
SQ   SEQUENCE   501 AA;  55566 MW;  4618C316745A7349 CRC64;
     MGNKQTKTDV ILIGAGIMSA TLGTLLKELA PEWDITVFER LEEAGVESSN EWNNAGTGHA
     ALCELNYTVE KPDGSIDISK AIKINEQFYV SLQFWAYLVN SGVLRDPKEF IRPLPHMSFV
     QGEDNVAFLK KRYETMVNNP LFKGMEFSDD PKKLAEWIPL MMENRVVNEP IAATRIESGT
     DVNFGALTRK LFEHLKRKNV EIHYRHHVDD IKRTSDGLWE LKVRDLDSGA VERHVAKFVF
     IGAGGGSLHL LQKSGIPEGR GIGGFPVSGL FMVCNNPDVV EQHHAKVYGK AKVGAPPMSV
     PHLDTRFINN QKMLLFGPFA GFSPKFLKNG SMLDLFTSVK PHNLLTMLAA GVKNMALTNY
     LIQQVMLSKE QRMEELREFV PTAKSEEWDV IVAGQRVQVI KDTEAGGKGT LQFGTEVVHA
     ADGSIAALLG ASPGASTAVH VMLEVITKCF PERMKEWEPK VREMIPSYGV SLMKNERLLH
     DVQAATAEML GLREGLALQL V