MQO_HAEDU
ID MQO_HAEDU Reviewed; 489 AA.
AC Q7VPC3;
DT 15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=HD_0165;
OS Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=233412;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=35000HP / ATCC 700724;
RA Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA Nguyen D., Wang J., Forst C., Hood L.;
RT "The complete genome sequence of Haemophilus ducreyi.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; AE017143; AAP95158.1; -; Genomic_DNA.
DR RefSeq; WP_010944212.1; NC_002940.2.
DR AlphaFoldDB; Q7VPC3; -.
DR STRING; 233412.HD_0165; -.
DR EnsemblBacteria; AAP95158; AAP95158; HD_0165.
DR KEGG; hdu:HD_0165; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_6; -.
DR OMA; PHLDTRW; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000001022; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; -; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1..489
FT /note="Probable malate:quinone oxidoreductase"
FT /id="PRO_0000128715"
SQ SEQUENCE 489 AA; 54372 MW; 47C0510F56F1181D CRC64;
MNHSDSTSYS DITLIGAGIM SATLGTLLAE LVPHKSITIF EQLAEVALES SNEWNNAGTG
HSALCELNYT EQNAQGEVKI ERAMKICEDF QLSLQLWSYL VEQGKIDKPQ EFIHRIPHIS
FVQGEDNVAF LRKRYQQLSG HHLFSGMQFS RDHAQLAKWM PLIMQNRSAT EILAASYIEN
GTDVNFGSLT RKLCAYLTQQ GKALKLMHRV KDIKQLANGD WQLTVLDQQQ QQIIHRTKFV
FIGCGGGSLP LLQKSAIDAG KKIGGFPVSG LFMVCRNPEL VAKHYAKVYG KAKLGAPPMS
VPHLDTRFID GKQSLLFGPF ASFTLKFLKQ GSVFDLPKSI QASNFSSVMA AGIKNLPLAN
YLIKQALLTK EQRMVELRDF IPDANSEDWQ VLVAGKRVQV LIDGEMRFGT EVVTAEDGSL
AVLLGASPGA SISVKAMLDV LLKCFSDELP AWQHKLQHML PSYQISLRDD AELYATLKRR
FEASLLLDQ