ID   MQO_HELAH               Reviewed;         450 AA.
AC   Q17VT7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=Hac_1519;
OS   Helicobacter acinonychis (strain Sheeba).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=382638;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sheeba;
RX   PubMed=16789826; DOI=10.1371/journal.pgen.0020120;
RA   Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G.,
RA   Gressmann H., Achtman M., Schuster S.C.;
RT   "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a
RT   host jump from early humans to large felines.";
RL   PLoS Genet. 2:1097-1110(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; AM260522; CAK00239.1; -; Genomic_DNA.
DR   RefSeq; WP_011578326.1; NC_008229.1.
DR   AlphaFoldDB; Q17VT7; -.
DR   STRING; 382638.Hac_1519; -.
DR   EnsemblBacteria; CAK00239; CAK00239; Hac_1519.
DR   KEGG; hac:Hac_1519; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_613842_0_0_7; -.
DR   OMA; DMGEAKI; -.
DR   OrthoDB; 1371190at2; -.
DR   BioCyc; HACI382638:HAC_RS06440-MON; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000000775; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..450
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000023805"
SQ   SEQUENCE   450 AA;  50498 MW;  6AE69DBBDCF129E0 CRC64;
     MSMEFDAVII GGGVSGCATF YTLSEYSSLK RVAIVEKCSK LAQISSSAKA NSQTIHDGSI
     ETNYTPEKAK KVRLSAYKTR QYALNKGLQN KAIFETQKMA IGVGDEECEF MKKRYESFKE
     IFVGLEEFDK QTIKELEPNV ILGASGIDRH ESIIGHGFRK DWSTMNYAKL SENFVEEALK
     LKPNNQVFLN FKVKKIEKRN DTYALISEDA EEVYAKFVLV NAGSYALPLA QSMGYGLDLG
     CLPVAGSFYF VPDLLKGKVY TVQNPKLPFA AVHGDPDAII KGKTRIGPTA LAMPKLERNK
     CWLKGISLEL LKMDLNKDVF KIAFDLMSDK EIRNYVLKNM VFELPVIGKR EFLKDAQKII
     PSLSLEDLEY AHGFGEVRPQ VLDKTKRKLE LGEKKICTHK GITFNMTPSP GATSCLQNAL
     VDSQEIVAYL GESFELERFY KDLSPEELES