ID   MQO_HELHP               Reviewed;         494 AA.
AC   Q7VFF6;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=HH_1720;
OS   Helicobacter hepaticus (strain ATCC 51449 / 3B1).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=235279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51449 / 3B1;
RX   PubMed=12810954; DOI=10.1073/pnas.1332093100;
RA   Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M.,
RA   Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R.,
RA   Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B.,
RA   Shen Z., Weber J., Frosch M., Fox J.G.;
RT   "The complete genome sequence of the carcinogenic bacterium Helicobacter
RT   hepaticus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; AE017125; AAP78317.1; -; Genomic_DNA.
DR   RefSeq; WP_011116559.1; NC_004917.1.
DR   AlphaFoldDB; Q7VFF6; -.
DR   STRING; 235279.HH_1720; -.
DR   EnsemblBacteria; AAP78317; AAP78317; HH_1720.
DR   KEGG; hhe:HH_1720; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_7; -.
DR   OMA; PHLDTRW; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002495; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..494
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000128716"
SQ   SEQUENCE   494 AA;  55520 MW;  DCC4ECF60A5041B0 CRC64;
     MSEDSEVVLV GGGIMSLTLA AMLRELKPSL HISVYEMFED LATESSSVWN NAGTGHQALC
     ELNYTPQKED GSIDVSKALK INQQFELSKE FWAYCIRKQI LKGAHTFLNP VPHLSFVVDD
     IVPYLKKRYE TLKDSPLFKN MIYTEDREQI KEWAPLLLEG RGETQKMAVT YMAGGSDVDF
     GEIARQFGEK LSQKEGFDVY THHKVRDLTK EGNIWLLDVI DTKSYERKQV KAKFVFLGAG
     GGSFPLLQKS GIPEGRGYGG FPVGGLWLIC NNREIIEKHN AKIYGKASIG DPPMSVPHLD
     TRIIRGKKEL LFGPYAGFNT KFLKKGSFFD FPSSIRLNNF IPMIQAGIDN VPLTIYLIKQ
     ILSTDRMRMR KLEVFFPAAQ FPDWNAQFAG QRVQVIKKDK NGRGSLQFGT EVITSSDGSL
     AALLGASPGA STVVDIMLEV LKRCFGDEMK TSAWQDKLAE MVPSYNRSLE ENITHFNECR
     LKTAQTLHLP FDEI