ID   MQO_LYSSC               Reviewed;         493 AA.
AC   B1HNU2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=Bsph_4711;
OS   Lysinibacillus sphaericus (strain C3-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX   NCBI_TaxID=444177;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C3-41;
RX   PubMed=18296527; DOI=10.1128/jb.01652-07;
RA   Hu X., Fan W., Han B., Liu H., Zheng D., Li Q., Dong W., Yan J., Gao M.,
RA   Berry C., Yuan Z.;
RT   "Complete genome sequence of the mosquitocidal bacterium Bacillus
RT   sphaericus C3-41 and comparison with those of closely related Bacillus
RT   species.";
RL   J. Bacteriol. 190:2892-2902(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000817; ACA42155.1; -; Genomic_DNA.
DR   RefSeq; WP_012296155.1; NC_010382.1.
DR   AlphaFoldDB; B1HNU2; -.
DR   EnsemblBacteria; ACA42155; ACA42155; Bsph_4711.
DR   KEGG; lsp:Bsph_4711; -.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   OMA; PHLDTRW; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002164; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..493
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000099875"
SQ   SEQUENCE   493 AA;  54324 MW;  ED14F52062307477 CRC64;
     MSNRQIKSDV ILIGAGIMSA TLGTILKELA PDWKITVFEK LEKAGEESSH ELNNAGTGHA
     ALCELNYTSE KKDGSIDIKK AINVNEQFQV SRQFWSYLVN NKLINNPQDF IMPLPHMSLV
     QGKENVEFLK KRHETMIQNP LFEGMEFSND PETLKKWIPL IMENRPAGED IAATKIDTGT
     DVNFGALTRM LIDHLKAKDV DVNYNHSVES LKQASDGSWE VRVHDLDGCK MEYHSAKFVF
     LGAGGGSLEL LQKSGIPEGK HIGGFPISGL FLACNNPEVA EQHHAKVYGK AKVGAPPMSV
     PHLDTRYIDN KKSLLFGPFA GFSPKFLKTG SNMDLFASVK PHNITTLLAA GVKEMGLTKY
     LIQQLMLSKE QRMEELREFI PNAKSDDWDI IVAGQRVQVI KDTEAGGKGT LQFGTEVVSA
     ADGSIAALLG ASPGASTAVH VMLEVINKCF PQHIKEWEAK IKEMIPSYGL SLAENPELLK
     EINATTDEAL RLK