ID   MQO_METFK               Reviewed;         492 AA.
AC   Q1GXL1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=Mfla_0011;
OS   Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=265072;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KT / ATCC 51484 / DSM 6875;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.;
RT   "Complete sequence of Methylobacillus flagellatus KT.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000284; ABE48282.1; -; Genomic_DNA.
DR   RefSeq; WP_011478379.1; NC_007947.1.
DR   AlphaFoldDB; Q1GXL1; -.
DR   STRING; 265072.Mfla_0011; -.
DR   EnsemblBacteria; ABE48282; ABE48282; Mfla_0011.
DR   KEGG; mfa:Mfla_0011; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_4; -.
DR   OMA; RHMAKAY; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002440; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..492
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000325499"
SQ   SEQUENCE   492 AA;  53861 MW;  F88AE0F979A814B2 CRC64;
     MTSSLDTDIL LVGGGIMSAT LGTLLHQLNP ELRITLVELQ AEVATESSDG WNNAGTGHAG
     YCELNYTPQD ADGSVPIARA LKINAAFEES LQFWAWLVEK GILREPASFI NPTPHSSFVW
     GEKNVAFLRK RHQALRAHHL FADMEYSQDP AVLQQWMPLV MAGRDPSIPV AATRVAYGSD
     VDFGSLTRQL VQHLQGRPGF KLLTRHAVTG LKQQGSWQVK AVDLSQGKPV EIRAGFVFLG
     AGGATLPLLQ KSAIQEARGY GGFPVSGQWL VCHNPDVIHQ HHAKVYGKAP LGAPPMSVPH
     LDTRIINGKP ALLFGPFAGF TTRFLKRGSL LDLVNSVKRS NLKSMLGAGR HHMDLTRYLI
     GEVFQSHQQR MAALRNFYPL ANESEWSLVS AGQRVQIIKQ CEHQGGKLEF GTEIVSSADG
     SLAALLGASP GASTSVPAML EVLQRCFSPQ LQSAAWQERM REMLPSYGQS LIEDAELLRA
     VRYHTLSRLK LT