MQO_MICLC
ID MQO_MICLC Reviewed; 494 AA.
AC C5CAA3;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=Mlut_08440;
OS Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 /
OS NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus).
OC Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Micrococcus.
OX NCBI_TaxID=465515;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC
RC 2665 / VKM Ac-2230;
RX PubMed=19948807; DOI=10.1128/jb.01254-09;
RA Young M., Artsatbanov V., Beller H.R., Chandra G., Chater K.F., Dover L.G.,
RA Goh E.B., Kahan T., Kaprelyants A.S., Kyrpides N., Lapidus A., Lowry S.R.,
RA Lykidis A., Mahillon J., Markowitz V., Mavromatis K., Mukamolova G.V.,
RA Oren A., Rokem J.S., Smith M.C., Young D.I., Greenblatt C.L.;
RT "Genome sequence of the Fleming strain of Micrococcus luteus, a simple
RT free-living actinobacterium.";
RL J. Bacteriol. 192:841-860(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; CP001628; ACS30372.1; -; Genomic_DNA.
DR RefSeq; WP_010078988.1; NZ_WBMF01000002.1.
DR AlphaFoldDB; C5CAA3; -.
DR STRING; 465515.Mlut_08440; -.
DR PRIDE; C5CAA3; -.
DR EnsemblBacteria; ACS30372; ACS30372; Mlut_08440.
DR KEGG; mlu:Mlut_08440; -.
DR PATRIC; fig|465515.4.peg.807; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_11; -.
DR OMA; PHLDTRW; -.
DR OrthoDB; 1371190at2; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000000738; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; -; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1..494
FT /note="Probable malate:quinone oxidoreductase"
FT /id="PRO_1000204201"
SQ SEQUENCE 494 AA; 53202 MW; 5952DD0742E06088 CRC64;
MPTTSSTATH DVVLIGGGIM SATLGVLLQK LEPTWSIALY ENLDQAGLES SDPWNNAGTG
HAALCELNYS PMDKNGRVDV TKALGINEQF WITRQFWSSL VVDGTLKDPK SFINPLPHMS
FVWGDDHADY LRARYEAMSA QPVFAGMEHS EDPEQIRAWA PLLIEGRESG QRLAASRHTG
GTDVDFGSLT RQLVTAMAGA GAEVRFGHKV TGLTRGTDGR WEVKVKNKAA GSEVVDRARF
VFVGAGGGAL PLLQKSGIPE IKGFGGFPVS GQFLRCTDES VVNQHMAKVY GQAAVGAPPM
SVPHLDTRFV NGKRSLLFGP YAGFSTNFLK TGSYLDLPLS VRPHNLTTML DVAKDNVDLT
KYLVTEVLKS RDKKIDALHE FYPEADGGEW ELITAGQRVQ VMKRKGRFGG VLQFGTEVVT
HADGSLGGLL GASPGASTAA PIMVKLLERC FPAKTAGWDG TLKELIPSLG HTLNDDPALL
DEVRTVTDAA LKLA
