ID   MQO_MYCBO               Reviewed;         493 AA.
AC   P65420; A0A1R3Y2J4; O05807; X2BM23;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Probable malate:quinone oxidoreductase;
DE            EC=1.1.5.4;
DE   AltName: Full=MQO;
DE   AltName: Full=Malate dehydrogenase [quinone];
GN   Name=mqo; OrderedLocusNames=BQ2027_MB2877C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU01497.1; -; Genomic_DNA.
DR   RefSeq; NP_856522.1; NC_002945.3.
DR   RefSeq; WP_003414545.1; NC_002945.4.
DR   AlphaFoldDB; P65420; -.
DR   EnsemblBacteria; SIU01497; SIU01497; BQ2027_MB2877C.
DR   GeneID; 45426839; -.
DR   PATRIC; fig|233413.5.peg.3155; -.
DR   OMA; PHLDTRW; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..493
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000128722"
SQ   SEQUENCE   493 AA;  53595 MW;  C3B4C469FF4F285F CRC64;
     MSDLARTDVV LIGAGIMSAT LGVLLRRLEP NWSITLIERL DAVAAESSGP WNNAGTGHSA
     LCEMNYTPEM PDGSIDITKA VRVNEQFQVT RQFWAYAAEN GILTDVRSFL NPVPHVSFVH
     GSRGVEYLRR RQKALAGNPL FAGTEFIESP DEFARRLPFM AAKRAFSEPV ALNWAADGTD
     VDFGALAKQL IGYCVQNGTT ALFGHEVRNL SRQSDGSWTV TMCNRRTGEK RKLNTKFVFV
     GAGGDTLPVL QKSGIKEVKG FAGFPIGGRF LRAGNPALTA SHRAKVYGFP APGAPPLGAL
     HLDLRFVNGK SWLVFGPYAG WSPKFLKHGQ ISDLPRSIRP DNLLSVLGVG LTERRLLNYL
     ISQLRLSEPE RVSALREFAP SAIDSDWELT IAGQRVQVIR RDERNGGVLE FGTTVIGDAD
     GSIAGLLGGS PGASTAVAIM LDVLQKCFAN RYQSWLPTLK EMVPSLGVQL SNEPALFDEV
     WSWSTKALKL GAA