MQO_MYCGI
ID MQO_MYCGI Reviewed; 518 AA.
AC A4TCE3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=Mflv_4052;
OS Mycolicibacterium gilvum (strain PYR-GCK) (Mycobacterium gilvum (strain
OS PYR-GCK)).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=350054;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PYR-GCK;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.;
RT "Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; CP000656; ABP46522.1; -; Genomic_DNA.
DR RefSeq; WP_011894902.1; NC_009338.1.
DR AlphaFoldDB; A4TCE3; -.
DR STRING; 350054.Mflv_4052; -.
DR EnsemblBacteria; ABP46522; ABP46522; Mflv_4052.
DR KEGG; mgi:Mflv_4052; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_11; -.
DR OMA; PHLDTRW; -.
DR OrthoDB; 1371190at2; -.
DR UniPathway; UPA00223; UER01008.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; -; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT CHAIN 1..518
FT /note="Probable malate:quinone oxidoreductase"
FT /id="PRO_1000078033"
FT REGION 495..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 55788 MW; BD59AFE2E14F142E CRC64;
MSEAEKTDVL LVGAGIMSAT LCALLRLLEP NWSMTLVERL DGAAAESSDP WNNAGTGHSA
LCELNYTPAR PDGSIDIAKA VNVNEQFQVS RQFWTYAVEN GVLPDVRSFL NPIPHVSFVT
GADNVQYLRK RYEALVGNPL FGTMEFIDDA GEFARRLPLM AEGRDLREPV GLNWTQDGTD
VDFGALSRQL LGFGAQQGMD TLFGHDVTNL SQNSDSTWTV KVVNRRTGRK RTFNAKFVFV
GAGGGALPLL QKAGIKEAKG FGGFPVGGQW LRTGNPELTA KHQAKVYGLP PLGAPPMSVP
HLDTRVINDK SWLLFGPFAG WSPKFLKQGK VTDLPFSVKP DNLVSMLGVG LTEMGLLKYL
IGQLLLSEAA RVENLREFAP SAKDSDWELD IAGQRVQVIR KAKGKGGVLE FGTTVLSAAD
GSIAGLLGAS PGASTAVPAM FDVMKRCFAD RYPSWEPKLK EMVPSLGVTL SDEPKLFEEV
WARGTKVLKL DKPAGAIPAT TDGQSTAGTE HTPTAATV
