MQO_MYCMM
ID MQO_MYCMM Reviewed; 493 AA.
AC B2HJU4;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=MMAR_1881;
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=216594;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M;
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; CP000854; ACC40330.1; -; Genomic_DNA.
DR RefSeq; WP_012393678.1; NC_010612.1.
DR AlphaFoldDB; B2HJU4; -.
DR STRING; 216594.MMAR_1881; -.
DR EnsemblBacteria; ACC40330; ACC40330; MMAR_1881.
DR KEGG; mmi:MMAR_1881; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_11; -.
DR OMA; PHLDTRW; -.
DR OrthoDB; 1371190at2; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; -; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1..493
FT /note="Probable malate:quinone oxidoreductase"
FT /id="PRO_1000099876"
SQ SEQUENCE 493 AA; 53718 MW; 2CB37A58630F54DE CRC64;
MSESARTDVV LVGAGIMSAT LGAMLRRLEP DWSITLIERL DAVAAESSGP WNNAGTGHSA
LCELNYTPQR PDGSIDISKA VRINEEFQVT RQFWAYAAEN GILNDVRSFL NPLPHVSFVH
GAERVHQLRR RRDALAGNPL FAGAEWIDDP DEFARRLPLM AAKRVFSEPI ALNWAADGTD
VDFGALSRQL IGYCVRNGAV ALFGQEVRNL VRQPDGGWML TVVNRRTGEK RKLKTKFVFV
GAGGNALSLL QRSGIKEING FAGFPIGGRF LRTANPALTA AHRAKVYGVP APGAPPLGAL
HLDLRYVNGK SWLMFGPFAG WSPKFLKRGH LRDLPGSIKP NNILSMVGVG VTQVTLLNYL
IGQLRLSEPD RVAVLRKFVP SAADSDWELI VAGQRVQVIR RDKRKGGVLE FGTTVVGEAD
GSIAGLLGGS PGASTAVPIM LEVLQRCFTH RYQSWLPALK EMVPSLGANL SEEPVLYDEV
RSWSSRALQL DAS