ID   MQO_MYCSK               Reviewed;         516 AA.
AC   A1UEQ5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=Mkms_2115;
OS   Mycobacterium sp. (strain KMS).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; unclassified Mycobacterium.
OX   NCBI_TaxID=189918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KMS;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Mycobacterium sp. KMS.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000518; ABL91313.1; -; Genomic_DNA.
DR   RefSeq; WP_011559467.1; NC_008705.1.
DR   AlphaFoldDB; A1UEQ5; -.
DR   STRING; 189918.Mkms_2115; -.
DR   EnsemblBacteria; ABL91313; ABL91313; Mkms_2115.
DR   KEGG; mkm:Mkms_2115; -.
DR   HOGENOM; CLU_028151_0_0_11; -.
DR   OMA; PHLDTRW; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..516
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000325503"
SQ   SEQUENCE   516 AA;  56003 MW;  EEC9685C404ACFEF CRC64;
     MSDAQVAKTD VVLVGAGIMS ATLSALIKLL EPNWSITLIE RLDGAAAESS DPWNNAGTGH
     SALCELNYTP EGPGGSIDIT KAVHVNEQFQ VSRQFWTYAV ENGVLPDVRN FINPIPHVSF
     VSGARNVEYL RARYDALVPN PLFATMEYID DRDEFARRLP FMADKRDFRE PVALNWSQDG
     TDIDFGSLSR QLIGYTAQRG MTTLFGHEVR DLDKQSDGSW SVKVVNRRTG AKRKLNAKFV
     FVGAGGGALP LLQKAGIEEA KGFGGFPVGG QWLRTGNPEL TARHQAKVYG MPPLGAPPMS
     VPHLDTRVIN GKSWLLFGPF AGWSPKFLKQ GKVTDLPFSV KPNNLASMLG VGLTEMGLLK
     YLIGQLLLSE ADRVETLRNF APSARDSDWE LDIAGQRVQV IRRKGKGGVL EFGTTVLAAK
     DGSIAGLLGA SPGASTAVPA MLDVMERCFG DRYTAWLPKL KEIVPSLGTK LSDEPKLFQE
     IWAHGTKVLK LDHPAAGLPV AGTDTEHREP ATTVTA