ID   MQO_MYCTU               Reviewed;         493 AA.
AC   P9WJP5; L0TDJ7; O05807; P65419;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Probable malate:quinone oxidoreductase;
DE            EC=1.1.5.4;
DE   AltName: Full=MQO;
DE   AltName: Full=Malate dehydrogenase [quinone];
GN   Name=mqo; OrderedLocusNames=Rv2852c; ORFNames=MTCY24A1.05;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45653.1; -; Genomic_DNA.
DR   PIR; G70589; G70589.
DR   RefSeq; NP_217368.1; NC_000962.3.
DR   RefSeq; WP_003414545.1; NZ_NVQJ01000006.1.
DR   AlphaFoldDB; P9WJP5; -.
DR   STRING; 83332.Rv2852c; -.
DR   PaxDb; P9WJP5; -.
DR   DNASU; 888544; -.
DR   GeneID; 45426839; -.
DR   GeneID; 888544; -.
DR   KEGG; mtu:Rv2852c; -.
DR   TubercuList; Rv2852c; -.
DR   eggNOG; COG0579; Bacteria.
DR   OMA; PHLDTRW; -.
DR   PhylomeDB; P9WJP5; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   1: Evidence at protein level;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..493
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000128721"
SQ   SEQUENCE   493 AA;  53595 MW;  C3B4C469FF4F285F CRC64;
     MSDLARTDVV LIGAGIMSAT LGVLLRRLEP NWSITLIERL DAVAAESSGP WNNAGTGHSA
     LCEMNYTPEM PDGSIDITKA VRVNEQFQVT RQFWAYAAEN GILTDVRSFL NPVPHVSFVH
     GSRGVEYLRR RQKALAGNPL FAGTEFIESP DEFARRLPFM AAKRAFSEPV ALNWAADGTD
     VDFGALAKQL IGYCVQNGTT ALFGHEVRNL SRQSDGSWTV TMCNRRTGEK RKLNTKFVFV
     GAGGDTLPVL QKSGIKEVKG FAGFPIGGRF LRAGNPALTA SHRAKVYGFP APGAPPLGAL
     HLDLRFVNGK SWLVFGPYAG WSPKFLKHGQ ISDLPRSIRP DNLLSVLGVG LTERRLLNYL
     ISQLRLSEPE RVSALREFAP SAIDSDWELT IAGQRVQVIR RDERNGGVLE FGTTVIGDAD
     GSIAGLLGGS PGASTAVAIM LDVLQKCFAN RYQSWLPTLK EMVPSLGVQL SNEPALFDEV
     WSWSTKALKL GAA