ID   MQO_NEIM0               Reviewed;         488 AA.
AC   A9M485;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=NMCC_2061;
OS   Neisseria meningitidis serogroup C (strain 053442).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=374833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=053442;
RX   PubMed=18031983; DOI=10.1016/j.ygeno.2007.10.004;
RA   Peng J., Yang L., Yang F., Yang J., Yan Y., Nie H., Zhang X., Xiong Z.,
RA   Jiang Y., Cheng F., Xu X., Chen S., Sun L., Li W., Shen Y., Shao Z.,
RA   Liang X., Xu J., Jin Q.;
RT   "Characterization of ST-4821 complex, a unique Neisseria meningitidis
RT   clone.";
RL   Genomics 91:78-87(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000381; ABX74179.1; -; Genomic_DNA.
DR   RefSeq; WP_002258396.1; NC_010120.1.
DR   AlphaFoldDB; A9M485; -.
DR   EnsemblBacteria; ABX74179; ABX74179; NMCC_2061.
DR   KEGG; nmn:NMCC_2061; -.
DR   HOGENOM; CLU_028151_0_0_4; -.
DR   OMA; PHLDTRW; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000001177; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..488
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000078034"
SQ   SEQUENCE   488 AA;  53896 MW;  F50FFF771917C78D CRC64;
     MAEATDVVLV GGGIMSATLG VLLKELEPSW EITLIERLED VALESSNAWN NAGTGHSALC
     ELNYAPLGAN GIIDPARALN IAEQFHVSRQ FWATLVAEGK LEDNSFINAV PHMSLVMNED
     HCSYLQKRYD AFKTQKLFEN MEFSTDRNKI SDWAPLMMRG RDENQPVAAN YSAEGTDVDF
     GRLTRQMVKY LQGKGVKTEF NRHVEDIKRE SDGAWVLKTA DTRNPDGQLT LRTRFLFLGA
     GGGALTLLQK SGIPEGKGYG GFPVSGLFFR NSNPETAGQH NAKVYGQASV GAPPMSVPHL
     DTRNVDGKRH LMFGPYAGFR SNFLKQGSLM DLPLSIHMDN LYPMLCAGWA NMPLTKYLLG
     ELRKTKEERF ASLLEYYPEA NPDDWELITA GQRVQIIKKD SEKGGVLQFG TEIVAHADGS
     LAALLGASPG ASTAVPLMIR LMHQCFPERA PSWEDRLKEL VPGYGIKLNE NPERADEIIA
     YTAKVLDI