ID   MQO_NEIMA               Reviewed;         488 AA.
AC   Q9JWK3; A1IPG5;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=NMA0333;
OS   Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS   Z2491).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15465 / Z2491;
RX   PubMed=10761919; DOI=10.1038/35006655;
RA   Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA   Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA   Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA   Barrell B.G.;
RT   "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT   Z2491.";
RL   Nature 404:502-506(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; AL157959; CAM07634.1; -; Genomic_DNA.
DR   PIR; B82029; B82029.
DR   RefSeq; WP_002246529.1; NC_003116.1.
DR   AlphaFoldDB; Q9JWK3; -.
DR   EnsemblBacteria; CAM07634; CAM07634; NMA0333.
DR   KEGG; nma:NMA0333; -.
DR   HOGENOM; CLU_028151_0_0_4; -.
DR   OMA; PHLDTRW; -.
DR   BioCyc; NMEN122587:NMA_RS01705-MON; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000000626; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..488
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000128723"
SQ   SEQUENCE   488 AA;  53993 MW;  4F3053EFA00F40F5 CRC64;
     MAEATDVVLV GGGIMSATLG VLLKELEPSW EITLIERLED VALESSNAWN NAGTGHSALC
     ELNYAPLGAN GIIDPARALN IAEQFHVSRQ FWATLVAEGK LEDNSFINAV PHMSLVMNED
     HCSYLQKRYD AFKTQKLFEN MEFSTDRNKI SDWAPLMMRG RDENQPVAAN YSAEGTDVDF
     GRLTRQMVKY LQGKGVKTEF NRHVEDIKRE SDGAWVLKTA DTRNPDGQLT LRTRFLFLGA
     GGGALTLLQK SGIPEGKGYG GFPVSGLFFR NSNPETAEQH NAKVYGQASV GAPPMSVPHL
     DTRNVDGKRH LMFGPYAGFR SNFLKQGSLM DLPLSIHMDN LYPMLRAGWA NMPLTKYLLG
     ELRKTKEERF ASLLEYYPEA NPDDWELITA GQRVQIIKKD SEKGGVLQFG TEIVAHADGS
     LAALLGASPG ASTAVPLMIR LMHQCFPERT PSWEGRLKEL VPGYGIKLNE NPERADEIIA
     YTAKVLDI