ID   MQO_NEIMF               Reviewed;         488 AA.
AC   A1KWH2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=NMC2076;
OS   Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM
OS   15464 / FAM18).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=272831;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700532 / DSM 15464 / FAM18;
RX   PubMed=17305430; DOI=10.1371/journal.pgen.0030023;
RA   Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C.,
RA   Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K.,
RA   Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S.,
RA   Quail M.A., Achtman M., Barrell B.G., Saunders N.J., Parkhill J.;
RT   "Meningococcal genetic variation mechanisms viewed through comparative
RT   analysis of serogroup C strain FAM18.";
RL   PLoS Genet. 3:230-240(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; AM421808; CAM11229.1; -; Genomic_DNA.
DR   RefSeq; WP_002223200.1; NC_008767.1.
DR   AlphaFoldDB; A1KWH2; -.
DR   EnsemblBacteria; CAM11229; CAM11229; NMC2076.
DR   KEGG; nmc:NMC2076; -.
DR   HOGENOM; CLU_028151_0_0_4; -.
DR   OMA; PHLDTRW; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002286; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..488
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000023811"
SQ   SEQUENCE   488 AA;  53897 MW;  1CF273AE12D36590 CRC64;
     MAEATDVVLV GGGIMSATLG VLLKELEPSW EITLIERLED VALESSNAWN NAGTGHSALC
     ELNYAPLGAN GIIDPARALN IAEQFHVSRQ FWATLVAEGK LEDNSFINAV PHMSLVMNED
     HCSYLQKRYD AFKTQKLFEN MEFSTDRNKI SDWAPLMMRG RDENQPVAAN YSAEGTDVDF
     GRLTRQMVKY LQGKGVKTEF NRHVEDIKRE SDGAWVLKTA DTRNPDGQLT LRTRFLFLGA
     GGGALTLLQK SGIPEGKGYG GFPVSGLFFR NSTPETAEQH NAKVYGQASV GAPPMSVPHL
     DTRNVDGKRH LMFGPYAGFR SNFLKQGSLM DLPLSIHMDN LYPMLCAGWA NMPLTKYLLG
     ELRKTKEERF ASLLEYYPEA NPDDWELITA GQRVQIIKKD SEKGGVLQFG TEIVAHADGS
     LAALLGASPG ASTAVPLMIR LMHQCFPERA PSWEGRLKEL VPGYGIKLNE NPERADEIIA
     YTAKVLDI