ID   MQO_OCEIH               Reviewed;         502 AA.
AC   Q8CV11;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=OB0946;
OS   Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS   3954 / HTE831).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=221109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX   PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT   and its unexpected adaptive capabilities to extreme environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; BA000028; BAC12902.1; -; Genomic_DNA.
DR   RefSeq; WP_011065348.1; NC_004193.1.
DR   AlphaFoldDB; Q8CV11; -.
DR   STRING; 221109.22776627; -.
DR   EnsemblBacteria; BAC12902; BAC12902; BAC12902.
DR   KEGG; oih:OB0946; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_9; -.
DR   OMA; PHLDTRW; -.
DR   OrthoDB; 1371190at2; -.
DR   PhylomeDB; Q8CV11; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000000822; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..502
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000128725"
SQ   SEQUENCE   502 AA;  56073 MW;  83625CF42D1515C8 CRC64;
     MSNKHTQADV ILIGAGIMSA TLGSLLKELS PNLEIRVFEK LENPGEESSN EWNNAGTGHS
     ALCELNYTSE RTDGSIDINK AVKVNEQFQL SRQFWSYLVN RNLIRNPEDF IRALPHISLV
     QGEDNVTFLR KRFKALVNHP LFNGMEFSDD NEKLKEWMPL IMDKRDTNEP IAATKIDSGT
     DVNFGALTRL LFQEFDHKGI DVNYNHSVED IKRNSEGLWE VKVHDMNDEK IEYHTAKFVF
     IGAGGGSLPL LQKTGIKESK HIGGFPVSGL FMVCNNPEVI EQHHAKVYGK AKVGAPPMSV
     PHLDTRFIDG KKSLLFGPFA GFSPKFLKTG SLFDLMHSVK SDNLFTMLSA GMKELPLTKY
     LIQQVVLSNE KRMEELREFI PNAQSKDWDI VIAGQRVQVI KDTEDGGKGT LQFGTEVVCG
     EDGTMAALLG ASPGASTAVH VMLEVIQKCF PEHLQEWEPK IKEMIPSYGI ALSENPELYK
     EIEVSIEKAL GLKNEEPMVI PS