ID   MQO_PROM1               Reviewed;         496 AA.
AC   A2C0M6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=NATL1_04721;
OS   Prochlorococcus marinus (strain NATL1A).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL1A;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABM75036.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000553; ABM75036.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041700671.1; NC_008819.1.
DR   AlphaFoldDB; A2C0M6; -.
DR   STRING; 167555.NATL1_04721; -.
DR   EnsemblBacteria; ABM75036; ABM75036; NATL1_04721.
DR   KEGG; pme:NATL1_04721; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_3; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002592; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..496
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000325509"
SQ   SEQUENCE   496 AA;  54802 MW;  973A19E04C9B9EE0 CRC64;
     MFNTPTPDSE NTYDAILVGA GIMSSTLAVL LHELEPDLRL LVVEKLSSAG LESSCAKNNA
     GTGHAANCEL NYTPIQEDGH LSTNKAFEIN KSFEQSLEFW ASLAEKGKLI PKTFLNKLPH
     ISLVFGDEDI SLLKKRFSKL SSHAAFAEME FTMDHGELKD WVPLIMDGRQ HSEKIAATRI
     KRGTDIDFGN LTRSYINQIE GAKSIDINYS TNVENLQQDS EGDWYLSLEG AKNNRIVRSK
     FVFLGAGGGA LSLLQKSRIP EGLLYAGFPV SGKWLICDEE KSTKTHNAKV YGKAAVGAPP
     MSVPHLDTRW IDKKKSLLFG PFAGFSSNFL KYGSKLDLFR SIKTTNLFSM LQAGLDNIDL
     GKYLLNQLIQ TNEDRIDTLK RFLPQVSPND WKLSTAGQRV QIIKQTSKGG VLKMGTEVVT
     SSDGSLAALL GASPGASTAV TIMIEVLNRC WLEKMKSSKW KNKMLELFPS IGTDINSDQE
     ALLAIRKRND FLLKLI