ID   MQO_PROM2               Reviewed;         498 AA.
AC   A8G3D1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=P9215_04961;
OS   Prochlorococcus marinus (strain MIT 9215).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=93060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9215;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000825; ABV50112.1; -; Genomic_DNA.
DR   RefSeq; WP_012007246.1; NC_009840.1.
DR   AlphaFoldDB; A8G3D1; -.
DR   STRING; 93060.P9215_04961; -.
DR   EnsemblBacteria; ABV50112; ABV50112; P9215_04961.
DR   KEGG; pmh:P9215_04961; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_3; -.
DR   OMA; PHLDTRW; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002014; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..498
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000325506"
SQ   SEQUENCE   498 AA;  55530 MW;  BFA6A348974476D3 CRC64;
     MTSSKNPTND NSYFDAVLVG GGIMSSTLAL LISEVLPDIK FLIIEKLNAP GSESTGAFNN
     AGTGHAANCE LNYTPLDEKG NLKIDKALSI NRSFETSMSL WASLYEAGKI DIKKFLKFIP
     HISFVSGQDN ISFLKKRFQK MTENPEFIDM EFSTSFDEIS SWAPLITKDR NPSTQIAATR
     IGRGTDINFE ALTKEYLSLV SLNKNVEIRY KTELIDLMKI DKKQWELEIS SEGRKTSIRT
     GYVFLGAGGK TINYLQKSKI PEAKSYGGFP VSGKWLICEK KDLTEKHNSK VYGKADIGSP
     PMSVPHLDTR WIDNKKLLLY GPFAGFTTKF LKQSSYFDLF SSIKKNNIFS MLDVGFKNND
     LINYLISQSL KSHNSRVENL KNMMPSANPS DWYLKNAGQR VQIIKKTEGG GSLKFGTEIV
     NSSDGSLSAL LGASPGASTA VSIMVEVLEK SVLFLNDKHN LKKKINDLIY PERTASQKNS
     TFIKEIKKRN NSIFGFHP