ID   MQO_PROM3               Reviewed;         496 AA.
AC   A2CBH2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=P9303_20971;
OS   Prochlorococcus marinus (strain MIT 9303).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9303;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000554; ABM78832.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2CBH2; -.
DR   STRING; 59922.P9303_20971; -.
DR   EnsemblBacteria; ABM78832; ABM78832; P9303_20971.
DR   KEGG; pmf:P9303_20971; -.
DR   HOGENOM; CLU_028151_0_0_3; -.
DR   OMA; PHLDTRW; -.
DR   BioCyc; PMAR59922:G1G80-1832-MON; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002274; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..496
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000023812"
SQ   SEQUENCE   496 AA;  53905 MW;  0B6611DFFE7C54CF CRC64;
     MAVSDVAGSQ SRYDAVLVGA GIMSATLAAL LHELDPELRL LMVERLQAPG LESSAAENNA
     GTGHAANCEL NYTPLQPDGS VATAKALAIN TAFERSLEFW ASLTEKGKLL PQQFLHLVPH
     ISVVFGDADL AFLHQRFQQL SALPAFASMQ WSTDAAELAE WMPLVMEGRA NAESVAATCI
     KRGTDVDFGL LTRAYVKSLQ ASGALELSCG CEVVHLHRLG KHRWNLDLKH SSGSRSVQTP
     FVFLGAGGGA LPLLQRSGIP EAAAYAGFPV SGQWLVCSEP GLTARHHAKV YGKAKVGAPP
     MSVPHLDSRW IDGCRSLLFG PYAGFSSKFL KQGSRLDLLR SVRRSNFRSM LEVGFKNFDL
     VTYLLSELQQ SEKDRFETLK QFLPNAQLND WKLSVAGQRV QIIKGTAEGG RLQMGTEVVS
     AEDGSLAALL GASPGASTAV TVMLEVLQRC WSERMASESW QERLQKLLPS YGHDPNSDPL
     LLMQMRIRSN ELLSFT