ID   MQO_PROM4               Reviewed;         500 AA.
AC   A9BE38;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=P9211_04171;
OS   Prochlorococcus marinus (strain MIT 9211).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=93059;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9211;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000878; ABX08348.1; -; Genomic_DNA.
DR   RefSeq; WP_012194971.1; NC_009976.1.
DR   AlphaFoldDB; A9BE38; -.
DR   STRING; 93059.P9211_04171; -.
DR   EnsemblBacteria; ABX08348; ABX08348; P9211_04171.
DR   KEGG; pmj:P9211_04171; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_3; -.
DR   OMA; PHLDTRW; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000000788; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..500
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000099878"
SQ   SEQUENCE   500 AA;  55497 MW;  A24CB79B1F26BEAE CRC64;
     MFISEAIGPE DRFDAVLIGA GIMSSTLAVL LHELDPCMRI LIVERLDSPA LESTSAFNNS
     GTGHAANCEF NYTPLQSNGR IEIEKALSIN SSFERSLEFW ASLAEMGRIS PATFLNFLPH
     ISFVWKEADL DFLKQRYLQL SSEVAFQRME WSDDKAELKE WMPIVMQGRP TSEKVAATRI
     QRGTDVDFGA LTRAYFDSLE ESGSVHIRLS TEVIDIQRFG QDPWKLFLKS DLNSYCVEGK
     FVFLGAGGGA LSLLQKSGIP EGKFYGGFPV SGQWLVCNET QVTNNHNAKV YGNADVGSPP
     MSVPHLDTRW IRGRKSLLFG PFAGFNTKFL KYGSNWDLFR SIQMGNVGAM VQAGLENIDL
     IKYLYGQLQQ DHISRVDSLQ NFLPNAKSKD WHLSLAGQRV QIIKKTSKGG KLKMGTEMVS
     SSDGSLAALL GASPGASTAV AIMIDLLRSS WGEKMSTKIW QDRLRRLIPS FGEDLNSNES
     MLKATRDRND SLLGFGEKNQ