ID   MQO_PROM5               Reviewed;         497 AA.
AC   A2BV78;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=P9515_04801;
OS   Prochlorococcus marinus (strain MIT 9515).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167542;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9515;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000552; ABM71689.1; -; Genomic_DNA.
DR   RefSeq; WP_011819797.1; NC_008817.1.
DR   AlphaFoldDB; A2BV78; -.
DR   STRING; 167542.P9515_04801; -.
DR   EnsemblBacteria; ABM71689; ABM71689; P9515_04801.
DR   KEGG; pmc:P9515_04801; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_3; -.
DR   OMA; PHLDTRW; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000001589; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..497
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000023813"
SQ   SEQUENCE   497 AA;  55883 MW;  E561FE082A24B688 CRC64;
     MTSKKFSDKK NNYDAILVGA GIMSGTLALL LTEILPELKI LIIEKLKIPG SESSGAFNNA
     GTGHAANCEL NYTPLDDYGH LKIEKALSIN RSFEKSMSLW ASLYSSQKID IKKFLKFIPH
     ISFVTGSENV SFLKKRFKKM TEYKEFEDME FSSSFNQISS WAPLITKSRN PLDEVAATRV
     KRGTDINFEV LTREYLKYIS KNKNVEISYE TELNDLKKTS NKEWELNISM EGRKVNLKTS
     YVFLGAGGKT INYLQKSNIP EAKVYGGFPV SGKWLICEEN SLTEKHNAKV YGRADIGSPP
     MSVPHLDTRW IEGKKFLLYG PFAGFTTKFL KQGSYLDLFN SLKKNNLLSM LDVGIKNNDL
     INYLFSQSIK SHKSRVENLR NMMPSADPSN WYLENAGQRV QIIKKTKKGG SLKFGTEIVN
     AADGSLSALL GASPGASTAV SIMIEVLKKS CLFTLDKSIL EQKISHLLYE SELKNQNEND
     FLENLKKRNN SILGFHP