ID   MQO_PROMA               Reviewed;         496 AA.
AC   Q7VDF8;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; Synonyms=mqoA;
GN   OrderedLocusNames=Pro_0418;
OS   Prochlorococcus marinus (strain SARG / CCMP1375 / SS120).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167539;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SARG / CCMP1375 / SS120;
RX   PubMed=12917486; DOI=10.1073/pnas.1733211100;
RA   Dufresne A., Salanoubat M., Partensky F., Artiguenave F., Axmann I.M.,
RA   Barbe V., Duprat S., Galperin M.Y., Koonin E.V., Le Gall F., Makarova K.S.,
RA   Ostrowski M., Oztas S., Robert C., Rogozin I.B., Scanlan D.J.,
RA   Tandeau de Marsac N., Weissenbach J., Wincker P., Wolf Y.I., Hess W.R.;
RT   "Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a
RT   nearly minimal oxyphototrophic genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10020-10025(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; AE017126; AAP99464.1; -; Genomic_DNA.
DR   RefSeq; NP_874812.1; NC_005042.1.
DR   RefSeq; WP_011124573.1; NC_005042.1.
DR   AlphaFoldDB; Q7VDF8; -.
DR   SMR; Q7VDF8; -.
DR   STRING; 167539.Pro_0418; -.
DR   EnsemblBacteria; AAP99464; AAP99464; Pro_0418.
DR   GeneID; 54199786; -.
DR   KEGG; pma:Pro_0418; -.
DR   PATRIC; fig|167539.5.peg.427; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_3; -.
DR   OMA; PHLDTRW; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000001420; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..496
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000128726"
SQ   SEQUENCE   496 AA;  54776 MW;  33F6F396671CB95B CRC64;
     MVLSDSLASD TRFDAVLIGA GIMSSTLAVL LHELDPEMRI LIVERLEAPA LESSSALNNA
     GTGHAANCEF NYTPCHPDGS INIQKALVIN SAFERSLEFW ASMTELGKLS PKTFLNLVPH
     ISFVNCEEDV LFLQQRYKKL SAINAFRDME WSADKEELSE WIPLIMNNRN PDQKVAATRV
     KRGTDINFGA LTLAYLETLQ ESGAVELKLS TEVVDISRLQ EETWEISLAN TAGTYCVQAP
     FLFLGAGGGA LSLLQNSGIE EGKKYGGFPV SGQWLVCNDS KLVKMHHAKV YGKSAIGAPP
     MSVPHLDTRW IGTERFLLFG PFAGFNTKFL KNGSNWDFLR SIQFSNFAPM IQTGLRNFDL
     IKYLIGQLKL DHDDRIAVLK DFFPEARSSN WTLSLAGQRV QIIKKTSKGG VLKLGTEVVT
     SSDGSLAALL GASPGASTAI SIMLEVLQRC WGKKMSTDIW QKRLRDLLPS FGQDINHDKS
     LLDKLRNRSD SLLGLR