ID   MQO_PROMS               Reviewed;         498 AA.
AC   A2BPP7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=A9601_04701;
OS   Prochlorococcus marinus (strain AS9601).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=146891;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AS9601;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; CP000551; ABM69758.1; -; Genomic_DNA.
DR   RefSeq; WP_011817926.1; NC_008816.1.
DR   AlphaFoldDB; A2BPP7; -.
DR   STRING; 146891.A9601_04701; -.
DR   EnsemblBacteria; ABM69758; ABM69758; A9601_04701.
DR   KEGG; pmb:A9601_04701; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_3; -.
DR   OMA; PHLDTRW; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002590; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..498
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000325505"
SQ   SEQUENCE   498 AA;  55590 MW;  41EE6FDB046DB448 CRC64;
     MTSSKNPTND NSYFDAVLVG AGIMSSTLAL LISEVLPDIK FLILEKLNAP GSESTGAFNN
     AGTGHAANCE LNYTPLDEKG NLIIDKALSI NRSFETSMSL WASLYEAGKI DIKKFLKFIP
     HISFVSGQDN ISFLKKRFQK MTENPEFIDM EFSTSFDEIS SWAPLITKDR NPSTQIAATR
     IDRGTDINFE ALTKEYLSLV SLNKNVEIRY KTELVDLKKI DKKQWELEIS SEGRKTSIRS
     GYVFLGAGGK TINYLQKSKI PEAKSYGGFP VSGKWLICEK KDLTEKHNSK VYGKADIGSP
     PMSVPHLDTR WIDNKKLLLY GPFAGFTTKF LKQSSYFDLF SSIKKNNIFS MLDVGFKNND
     LINYLISQSL KNHNSRVENL KNMMPSANPS DWYLKNAGQR VQIIKKTEGG GSLKFGTEIV
     NSSDGSLSAL LGASPGASTA VSIMVEVLEK SVLFLNDKHN LQKKINDLIY PELSVSENYS
     TFIKEIKKRN NSIFGFHP