ID   MQO_PROMT               Reviewed;         496 AA.
AC   Q46GZ7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=PMN2A_1753;
OS   Prochlorococcus marinus (strain NATL2A).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL2A;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAZ59241.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000095; AAZ59241.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041710934.1; NC_007335.2.
DR   AlphaFoldDB; Q46GZ7; -.
DR   STRING; 59920.PMN2A_1753; -.
DR   EnsemblBacteria; AAZ59241; AAZ59241; PMN2A_1753.
DR   KEGG; pmn:PMN2A_1753; -.
DR   HOGENOM; CLU_028151_0_0_3; -.
DR   OrthoDB; 1371190at2; -.
DR   PhylomeDB; Q46GZ7; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002535; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..496
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000325510"
SQ   SEQUENCE   496 AA;  54782 MW;  069FCF8FDAC8A3C3 CRC64;
     MFNTGTPDSE NTYDAILVGA GIMSSTLAVL LHELEPDLRL LVVEKLSSAG LESSCAKNNA
     GTGHAANCEL NYTPIQEDGH LSTTKAFEIN KSFEQSLEFW ASLAEKGKLI PKTFLNKLPH
     ISLVFGDEDI SLLKKRFSKL SSHAAFAKME FTMDHGELQD WIPLIMDGRK QSEKIAATRI
     KRGTDIDFGN LTRSYINQIE GAKSIDINYS TNVENLQQDS EGDWYLSLEG AKKNRIVRSK
     FVFLGAGGGA LSLLQKSRIP EGLLYAGFPV SGKWLICDEE KSTKTHNAKV YGKAAVGAPP
     MSVPHLDTRW IDKKKSLLFG PFAGFSSNFL KYGSKLDLFR SIKTTNLFSM LQAGLDNIDL
     GKYLLNQLIQ TNEDRIDTLK RFLPQVSPND WKLSTAGQRV QIIKQTSKGG VLKMGTEVVT
     SSDGSLAALL GASPGASTAV TIMIEVLNRC WQEKMKSSKW KNKMLELFPS IGTDINSDQE
     ALLAIRKRND FLLKLI