MQO_RENSM
ID MQO_RENSM Reviewed; 495 AA.
AC A9WQR6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212};
GN OrderedLocusNames=RSal33209_1912;
OS Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 /
OS NBRC 15589 / NCIMB 2235).
OC Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Renibacterium.
OX NCBI_TaxID=288705;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235;
RX PubMed=18723615; DOI=10.1128/jb.00721-08;
RA Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S.,
RA Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H.,
RA Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.;
RT "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests
RT reductive evolution away from an environmental Arthrobacter ancestor.";
RL J. Bacteriol. 190:6970-6982(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC Rule:MF_00212}.
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DR EMBL; CP000910; ABY23645.1; -; Genomic_DNA.
DR RefSeq; WP_012245316.1; NC_010168.1.
DR AlphaFoldDB; A9WQR6; -.
DR SMR; A9WQR6; -.
DR STRING; 288705.RSal33209_1912; -.
DR PRIDE; A9WQR6; -.
DR EnsemblBacteria; ABY23645; ABY23645; RSal33209_1912.
DR KEGG; rsa:RSal33209_1912; -.
DR eggNOG; COG0579; Bacteria.
DR HOGENOM; CLU_028151_0_0_11; -.
DR OMA; PHLDTRW; -.
DR OrthoDB; 1371190at2; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000002007; Chromosome.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; -; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW Tricarboxylic acid cycle.
FT CHAIN 1..495
FT /note="Probable malate:quinone oxidoreductase"
FT /id="PRO_1000078035"
SQ SEQUENCE 495 AA; 53745 MW; 8154744C10162717 CRC64;
MTFISQTKEA DVVFIGGGIM SATLGAMIRQ IQPDWSVVVF EQLNELGQES SGPWNNAGTG
HSALCELNYT PAAKDGSVEA SKALAINEQF QLSRQFWSHM VDKQFIGSPK NFINTVPHMS
FVMGKDHTDF LRTRYEALKP NPLFSSMEFS SDPSQIEKWA PLVMKGRSGN GPVAATRAAE
GTDVDFGQLT KELVGYLGNN DAEINYGTTV TDIQRGTDKR WHLKLKHKAS GEHGAIKARF
VFIGSGGGAL HLLQRSGIPQ GKGYGGFPVS GQFFRCTNEE IAAQHSAKVY GQASVGAPPM
SVPHLDTRYV GGKKSLLFGP YAGFSTNFLK SGSLWDLPLS IRPSNIYPMA AAGLHNLGLT
KYLVSEVLKT RSSKVTAMQE YFPQADGNDW ELITAGQRVQ IMKKDRKQGG ILQFGTEVIT
SSDGSIGALL GASPGASTAV PIMLELLQRC FPREFKLQWQ DQLKDMIPTL GTKLNDNAEL
AAATMARTAA TLQLD
