ID   MQO_RHOE4               Reviewed;         512 AA.
AC   C0ZY77;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=RER_26040;
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus;
OC   Rhodococcus erythropolis group.
OX   NCBI_TaxID=234621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT   PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; AP008957; BAH33312.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0ZY77; -.
DR   STRING; 234621.RER_26040; -.
DR   EnsemblBacteria; BAH33312; BAH33312; RER_26040.
DR   KEGG; rer:RER_26040; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_11; -.
DR   OMA; PHLDTRW; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..512
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000204203"
SQ   SEQUENCE   512 AA;  55188 MW;  467BE7307820C5FA CRC64;
     MSNQNAVETK TDVVLVGAGI MSATLGALLR QLQPDWSIST FERLDAVAAE SSDPWNNAGT
     GHSALCELNY TPENSDGTVD IKKAVNVNEQ FQVSRQFWAH AVEQGVLTQP KEFINPIPHV
     SFVHGEANAK YLRARYDALA GHTLFRGMEY IDDPAEFSER LPLMAKGRDF SDPIALNWSQ
     DGTDVDFGAL TKQLIGYIGK TGGKMYFGHE VTNLTQNSDK SWTVKVTNRR TGEKRTVRSR
     FVFVGAGGGA LHLLQKSGIK EAKGFGGFPV SGAFLRCTNP ELIDQHSAKV YGKAAVGAPP
     MSVPHLDTRV IGNKPGLLFG PYAGWSPKFL KQGRVTDLPG SVKPNNILSM LGVGVSELGL
     VKYLVSELAK NEAGRIWDLR EFAPKAQAQD WELITAGQRV QVIRRAKGKG GVLEFGTAVV
     AAEDGSIAGL LGASPGASTA VPAMLDVLER CFPTEFQGWK GKLREMVPSI GVKLTDNEGL
     FNQVWDWSSK VLELDSAGAS ESAPVADTVA TV