ID   MQO_RHOJR               Reviewed;         506 AA.
AC   Q0S251;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=RHA1_ro06612;
OS   Rhodococcus jostii (strain RHA1).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=101510;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHA1;
RX   PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA   McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C.,
RA   Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H.,
RA   Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H.,
RA   Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R.,
RA   Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W.,
RA   Eltis L.D.;
RT   "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT   catabolic powerhouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABG98385.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000431; ABG98385.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q0S251; -.
DR   SMR; Q0S251; -.
DR   STRING; 101510.RHA1_ro06612; -.
DR   EnsemblBacteria; ABG98385; ABG98385; RHA1_ro06612.
DR   KEGG; rha:RHA1_ro06612; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_11; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000008710; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..506
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000325511"
SQ   SEQUENCE   506 AA;  54325 MW;  37A2ECA277BAE981 CRC64;
     MSDQNAVETR TDVVLVGAGI MSATLGAILR QVQPDWSITT FERLDAVAAE SSDPWNNAGT
     GHSALCELNY TPQNADGTVD ITKAVNVNEQ FQVSRQFWAH GVESGVLTQP KEFINPIPHV
     SFVHGEANAK YLRARYDALA GHPLFAGMEY IDAPDEFTRR LPLMAKGRDF SDPVALNWTQ
     DGTDVDFGAL TKQLLGYVGA SGGVVHFGHE VTDLTKQSDG SWVVKVTNRR NGVKKVVRAK
     FVFVGAGGGA LHLLQKSGIE EAKGFGGFPV SGAFLRCTNP ELIDQHRAKV YGKAAVGAPP
     MSVPHLDTRV IGNKPGLLFG PYAGWSPKFL KQGRVTDLPS SVKPDNLLSM LGVGVSELGL
     VKYLISELAM SEAGRIETLR EFVPKALGKD WELITAGQRV QVIRRAKGKG GVLEFGTAVV
     NAADGTIAGL LGASPGASTA VPAMLDVLQR CFPAQYESWK PKLQEMVPSL GVKLSDDTAL
     FSQVWDWTSK VLQLDTSKVE DASVAV