ID   MQO_STRMK               Reviewed;         562 AA.
AC   B2FSQ8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=Smlt1234;
OS   Stenotrophomonas maltophilia (strain K279a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Stenotrophomonas; Stenotrophomonas maltophilia group.
OX   NCBI_TaxID=522373;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K279a;
RX   PubMed=18419807; DOI=10.1186/gb-2008-9-4-r74;
RA   Crossman L.C., Gould V.C., Dow J.M., Vernikos G.S., Okazaki A.,
RA   Sebaihia M., Saunders D., Arrowsmith C., Carver T., Peters N., Adlem E.,
RA   Kerhornou A., Lord A., Murphy L., Seeger K., Squares R., Rutter S.,
RA   Quail M.A., Rajandream M.A., Harris D., Churcher C., Bentley S.D.,
RA   Parkhill J., Thomson N.R., Avison M.B.;
RT   "The complete genome, comparative and functional analysis of
RT   Stenotrophomonas maltophilia reveals an organism heavily shielded by drug
RT   resistance determinants.";
RL   Genome Biol. 9:R74.1-R74.13(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; AM743169; CAQ44790.1; -; Genomic_DNA.
DR   RefSeq; WP_012479432.1; NC_010943.1.
DR   AlphaFoldDB; B2FSQ8; -.
DR   STRING; 522373.Smlt1234; -.
DR   EnsemblBacteria; CAQ44790; CAQ44790; Smlt1234.
DR   GeneID; 61465153; -.
DR   KEGG; sml:Smlt1234; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_6; -.
DR   OMA; PHLDTRW; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000008840; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..562
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_1000099882"
SQ   SEQUENCE   562 AA;  61477 MW;  C08AE367135C317B CRC64;
     MKKFGKALLA LLVLLLLAAA LFLYWPLTQR SVPAASNDKP VDVVLVGAGI MSITLATYLQ
     ELQPDWNIQV YERLDGVAGE SSDGWNNAGT GHSAFAELNY TPELPDGSIE TKRAVGIAES
     FEVSRQFWSH QVKEGRLSQP SDFINPTPHM SFVWGDDNIA YLHKRQQALV KNPLFYGMQY
     SEDPAQIKQW APLLMEGRDP KQKVAATWMP LGTDVNFGVI TRQLTAGLQR SPNFSLHLNH
     EVSALRQNAD KSWNVTVKDL KAGTESTTHA RFVFIGAGGA ALKLLQMSGI PESKDYAGFP
     VGGQFLAFQG QDVTSRHGVK AYGMAETGSP PMSVPHLDAR KLDGKPVVLF GPFALYSTKF
     LKHGSWWDLY SSVNHNNVGP MLEVGKDNLD LVQYLMGQAR LNDADRQAEL VKYFPTAKPG
     DWKLVTAGQR VQIIKRDPLK GPVLQFGTEI VTDKDHTLAA LLGASPGAST SPPIMLDLMA
     KAFPDQMKAG WEARLREIVP SYGRKLNDSA ALVNEIRTLT SQTLHLPYLE VPVDANAASP
     AAAAVPAAAK EKRNANEELQ AL