ID   MQO_WIGBR               Reviewed;         510 AA.
AC   Q8D1V2;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo {ECO:0000255|HAMAP-Rule:MF_00212}; OrderedLocusNames=WIGBR6040;
OS   Wigglesworthia glossinidia brevipalpis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Wigglesworthia.
OX   NCBI_TaxID=36870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12219091; DOI=10.1038/ng986;
RA   Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M.,
RA   Aksoy S.;
RT   "Genome sequence of the endocellular obligate symbiont of tsetse flies,
RT   Wigglesworthia glossinidia.";
RL   Nat. Genet. 32:402-407(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; BA000021; BAC24750.1; -; Genomic_DNA.
DR   RefSeq; WP_011070408.1; NC_004344.2.
DR   AlphaFoldDB; Q8D1V2; -.
DR   STRING; 36870.25166560; -.
DR   EnsemblBacteria; BAC24750; BAC24750; BAC24750.
DR   KEGG; wbr:yojH; -.
DR   eggNOG; COG0579; Bacteria.
DR   HOGENOM; CLU_028151_0_0_6; -.
DR   OMA; PHLDTRW; -.
DR   OrthoDB; 1371190at2; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000000562; Chromosome.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..510
FT                   /note="Probable malate:quinone oxidoreductase"
FT                   /id="PRO_0000128758"
SQ   SEQUENCE   510 AA;  57926 MW;  47B5D88EFFD4BAAA CRC64;
     MNKKNHEDSN SFKKYSAIKE NDSVDVVLIG SGIMSATLGI YLKLLEPNWI IHSYERLNKV
     GQESSNAWNN AGTGHSAFCE LNYTSINKDG SINISKAIKV NESFEISKQL WAYLIKEKIL
     VNSSSFINTV PHMSFVWGEN NINFLKKRFF YLKQNALFKD MLYSENYDII KKWAPLIMEG
     RSINEKVAAT RMEIGTDVNF GEITKQIFYY LKNKSNFFLY LNHDVIDIIR NKDKTWCLKV
     VDNILKKTIK INSKYVFIGS GGGALKLLQK SKIEQSIGYA GFPVGGQFLV TKNKKLTNNH
     QAKVYGKSPI GAPPMSVPHI DTRIINGEKV LLFGPFATFS SKFLKNGSYF DLFSSLTKEN
     IIPILQVGIN NFNLVKYLIN QLLKSKRGKF NDLCKYLPTA KMKDWSLITA GQRVQIIKKD
     IEKGGILEFG TEIINSKDCT LSALLGASPG ASTSASTMLD LLKIMFYDKI NKSEWKSKLN
     KIFISYNKKI HESYEYTLEI RNYTSKILSL