ID   MR1AL_DANRE             Reviewed;         152 AA.
AC   P51047;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Melatonin receptor type 1A-like;
DE            Short=Mel-1A-R-like;
DE            Short=Mel1a receptor-like;
DE   AltName: Full=Melatonin receptor Mel1a Z1.4;
DE   AltName: Full=zMel1a-2;
DE   Flags: Fragment;
GN   Name=mtnr1al; Synonyms=mel1a, mtnr1a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7576645; DOI=10.1016/0896-6273(95)90090-x;
RA   Reppert S.M., Weaver D.R., Cassone V.M., Godson C., Kolakowski L.F. Jr.;
RT   "Melatonin receptors are for the birds: molecular analysis of two receptor
RT   subtypes differentially expressed in chick brain.";
RL   Neuron 15:1003-1015(1995).
RN   [2]
RP   INDUCTION.
RX   PubMed=17622340; DOI=10.1371/journal.pone.0000587;
RA   Shang E.H., Zhdanova I.V.;
RT   "The circadian system is a target and modulator of prenatal cocaine
RT   effects.";
RL   PLoS ONE 2:E587-E587(2007).
CC   -!- FUNCTION: High affinity receptor for melatonin. The activity of this
CC       receptor is mediated by pertussis toxin sensitive G proteins that
CC       inhibits adenylate cyclase activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: By cocaine, which increases the levels of day-time
CC       expression. {ECO:0000269|PubMed:17622340}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U31823; AAA92495.1; -; mRNA.
DR   AlphaFoldDB; P51047; -.
DR   SMR; P51047; -.
DR   STRING; 7955.ENSDARP00000124268; -.
DR   PaxDb; P51047; -.
DR   ZFIN; ZDB-GENE-990415-154; mtnr1al.
DR   eggNOG; ENOG502QUZ5; Eukaryota.
DR   InParanoid; P51047; -.
DR   PhylomeDB; P51047; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000025; Melatonin_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00857; MELATONINR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Cell membrane; G-protein coupled receptor; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           <1..>152
FT                   /note="Melatonin receptor type 1A-like"
FT                   /id="PRO_0000069744"
FT   TOPO_DOM        <1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        14..34
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..58
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..111
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..144
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..>152
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         152
SQ   SEQUENCE   152 AA;  17634 MW;  00962009057759AD CRC64;
     CHSLKYDKLF SNKNTVCYVI LVWALTVLAI VPNWFVESLQ YDPRVFSCTF AQSVSSLYTI
     MVVVVHFIVP IGIVTYCYLR IWILVIQVPR RVKPDSRPKI KPHDFRNFLT MFVVFVLFAV
     CWAPLNFIGL AVAIHPRLGQ SIPEWLFTAS YF