MR1BB_DANRE
ID MR1BB_DANRE Reviewed; 347 AA.
AC P51049; Q5RGH4; Q804I8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Melatonin receptor type 1B-B;
DE Short=Mel-1B-R-B;
DE Short=Mel1b receptor B;
DE AltName: Full=Melatonin receptor Mel1b Z2.6-4;
DE AltName: Full=zMel1b-1;
GN Name=mtnr1bb; Synonyms=mel1br, mtnr1br, mtnr1br-2;
GN ORFNames=si:ch211-214k5.4, si:ch211-224h1.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-233.
RA Danilova N.P.;
RT "Zebrafish melatonin receptors.";
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 134-286.
RX PubMed=7576645; DOI=10.1016/0896-6273(95)90090-x;
RA Reppert S.M., Weaver D.R., Cassone V.M., Godson C., Kolakowski L.F. Jr.;
RT "Melatonin receptors are for the birds: molecular analysis of two receptor
RT subtypes differentially expressed in chick brain.";
RL Neuron 15:1003-1015(1995).
RN [4]
RP INDUCTION.
RX PubMed=17622340; DOI=10.1371/journal.pone.0000587;
RA Shang E.H., Zhdanova I.V.;
RT "The circadian system is a target and modulator of prenatal cocaine
RT effects.";
RL PLoS ONE 2:E587-E587(2007).
CC -!- FUNCTION: High affinity receptor for melatonin. The activity of this
CC receptor is mediated by pertussis toxin sensitive G proteins that
CC inhibits adenylate cyclase activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- INDUCTION: By cocaine, which increases the levels of day-time
CC expression. {ECO:0000269|PubMed:17622340}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BX897671; CAI11795.1; -; Genomic_DNA.
DR EMBL; CR933018; CAM14076.1; -; Genomic_DNA.
DR EMBL; AY166826; AAO23297.1; -; mRNA.
DR EMBL; U31824; AAA92496.1; -; mRNA.
DR RefSeq; NP_571469.1; NM_131394.1.
DR AlphaFoldDB; P51049; -.
DR SMR; P51049; -.
DR STRING; 7955.ENSDARP00000072688; -.
DR PaxDb; P51049; -.
DR Ensembl; ENSDART00000078226; ENSDARP00000072688; ENSDARG00000086493.
DR Ensembl; ENSDART00000181941; ENSDARP00000147236; ENSDARG00000086493.
DR GeneID; 30668; -.
DR KEGG; dre:30668; -.
DR CTD; 30668; -.
DR ZFIN; ZDB-GENE-990415-156; mtnr1bb.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000166267; -.
DR HOGENOM; CLU_009579_3_3_1; -.
DR InParanoid; P51049; -.
DR OMA; RLFFQDT; -.
DR OrthoDB; 907115at2759; -.
DR PhylomeDB; P51049; -.
DR TreeFam; TF331693; -.
DR PRO; PR:P51049; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 10.
DR Bgee; ENSDARG00000086493; Expressed in dorsal caudal thalamic nucleus and 7 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002278; Mel_1A/1B_rcpt.
DR InterPro; IPR000025; Melatonin_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01149; MELATONIN1AR.
DR PRINTS; PR00857; MELATONINR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Biological rhythms; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..347
FT /note="Melatonin receptor type 1B-B"
FT /id="PRO_0000069745"
FT TOPO_DOM 1..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..191
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 25
FT /note="A -> P (in Ref. 2; AAO23297)"
FT /evidence="ECO:0000305"
FT CONFLICT 63
FT /note="R -> K (in Ref. 2; AAO23297)"
FT /evidence="ECO:0000305"
FT CONFLICT 143
FT /note="Y -> C (in Ref. 3; AAA92496)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 347 AA; 38979 MW; 5BB93B61AE83D563 CRC64;
MPENIAFLTN STDLGHVGRA LGSSARPAWA IAVLASVLIF TTVVDVLGNL LVIISVFRNR
KLRNAGNVFV VSLAFADLVV AFYPYPLVLY AIFHDGWSLG ETQCKISGFL MGLSVIGSVF
NITGIAINRY CYICHSFAYG RLYSFRNTLL LVALIWALTV LAILPNFFVG SLSYDPRVYS
CTFTQTASSS YTVVVVVVHF LVPIAVVTFC YLRIWVLVIQ VRRKVKSEER SRVRPSDLRN
FVTMFVVFVL FAICWAPLNL IGLVVAINPE VMAPRVPEWL FVVSYFMAYF NSCLNAIIYG
LLNRNFRKEY VRIMTAVWIP RRFVTETSRA ATDGMRSKPS PAINNNE
